› 6pbx

Electron Microscopy
4Å resolution

Single particle cryo-EM structure of the voltage-gated K+ channel Eag1 3-13 deletion mutant bound to calmodulin (conformation 2)

Released:
DOI: 10.2210/pdb6pbx/pdb
PDB entry 6pbx coloured by chain, front view.
PDB entry 6pbx coloured by chain, side view.
PDB entry 6pbx coloured by chain, top view.
Source organisms:
Primary publication:
Regulation of Eag1 gating by its intracellular domains.
Whicher JR, MacKinnon R
Elife 8 (2019)
PMID: 31490124
Related structures: EMD-20294

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero octamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-143998 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Potassium voltage-gated channel subfamily H member 1 Chains: A, C, E, G
Molecule details ›
Chains: A, C, E, G
Length: 846 amino acids
Theoretical weight: 96.26 KDa
Source organism: Rattus norvegicus
Expression system: Homo sapiens
UniProt:
  • Canonical: Q63472 (Residues: 14-962; Coverage: 87%)
Gene names: Eag, Kcnh1
Sequence domains:
Calmodulin-1 Chains: B, D, F, H
Molecule details ›
Chains: B, D, F, H
Length: 149 amino acids
Theoretical weight: 16.85 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P0DP23 (Residues: 1-149; Coverage: 100%)
Gene names: CALM, CALM1, CAM, CAM1
Sequence domains: EF-hand domain pair

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 4Å
Relevant EMDB volumes: EMD-20294
Expression system: Homo sapiens

Quick links

Citations

2 review citations

The EAG Voltage-Dependent K+ Channel Subfamily: Similarities and Differences in Structural Organization and Gating.
Barros et al. (2020)
1 more

3 mentions without citation

The chemistry of snake venom and its medicinal potential.
Oliveira et al. (2022)
2 more