› 6pcx

X-ray diffraction
2.11Å resolution

Crystal Structure of a H5N1 influenza virus hemagglutinin at pH 6.0

Released:
DOI: 10.2210/pdb6pcx/pdb
Model geometry
Fit model/data
PDB entry 6pcx coloured by chain, front view.
PDB entry 6pcx coloured by chain, side view.
PDB entry 6pcx coloured by chain, top view.
Source organism: Influenza A virus (A/mallard/Vietnam/3/2003(H5N1))
Primary publication:
Identification of a pH sensor in Influenza hemagglutinin using X-ray crystallography.
Antanasijevic A, Durst MA, Lavie A, Caffrey M
OpenAccess logo J Struct Biol 209 107412 (2020)
PMID: 31689502

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-172930 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Hemagglutinin Chain: A
Molecule details ›
Chain: A
Length: 526 amino acids
Theoretical weight: 59.84 KDa
Source organism: Influenza A virus (A/mallard/Vietnam/3/2003(H5N1))
Expression system: Trichoplusia ni
UniProt:
  • Canonical: Q1KHJ9 (Residues: 17-521; Coverage: 89%)
Gene name: HA
Sequence domains: Haemagglutinin

Ligands and Environments

3 bound ligands:
Ligand SO4 12 x SO4
Ligand GOL 3 x GOL
Ligand NAG 4 x NAG
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: APS BEAMLINE 21-ID-G
Spacegroup: R32
Unit cell:
a: 108.537Å b: 108.537Å c: 419.79Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.209 0.207 0.255
Expression system: Trichoplusia ni

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Citations

3 review citations

Hemagglutinin Stability and Its Impact on Influenza A Virus Infectivity, Pathogenicity, and Transmissibility in Avians, Mice, Swine, Seals, Ferrets, and Humans.
Russell CJ. (2021)
2 more

4 mentions without citation

Epitopes in the HA and NA of H5 and H7 avian influenza viruses that are important for antigenic drift.
Luczo et al. (2024)
3 more