› 6pgw

X-ray diffraction
3Å resolution

Crystal structure of zebrafish Protocadherin-19 EC3-6

Released:
DOI: 10.2210/pdb6pgw/pdb
Model geometry
Data not analysed
Fit model/data
Data not analysed
PDB entry 6pgw coloured by chain, front view.
PDB entry 6pgw coloured by chain, side view.
PDB entry 6pgw coloured by chain, top view.
Source organism: Danio rerio
Primary publication:
A complete Protocadherin-19 ectodomain model for evaluating epilepsy-causing mutations and potential protein interaction sites.
Hudson JD, Tamilselvan E, Sotomayor M, Cooper SR
Structure 29 1128-1143.e4 (2021)
PMID: 34520737

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-123742 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Protocadherin-19 Chain: A
Molecule details ›
Chain: A
Length: 443 amino acids
Theoretical weight: 48.83 KDa
Source organism: Danio rerio
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: F8W3X3 (Residues: 237-670; Coverage: 41%)
Gene name: pcdh19
Sequence domains: Cadherin domain

Ligands and Environments

2 bound ligands:
Ligand CA 9 x CA
Ligand NA 1 x NA
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: APS BEAMLINE 24-ID-C
Spacegroup: P21
Unit cell:
a: 69.92Å b: 58.896Å c: 70.956Å
α: 90° β: 117.97° γ: 90°
R-values:
R R work R free
0.219 0.215 0.298
Expression system: Escherichia coli BL21

Quick links

Citations

2 citation in other articles

How clustered protocadherin binding specificity is tuned for neuronal self-/nonself-recognition.
Goodman et al. (2022)
1 more