› 6pjj

X-ray diffraction
2.4Å resolution

Human PRPF4B bound to benzothiophene inhibitor 224

Released:
DOI: 10.2210/pdb6pjj/pdb
PDB entry 6pjj coloured by chain, front view.
PDB entry 6pjj coloured by chain, side view.
PDB entry 6pjj coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Godoi PHC, Santiago AS, Fala AM, Ramos PZ, Sriranganadane D, Mascarello A, Segretti N, Azevedo H, Guimaraes CRW, Arruda P, Elkins JM, Counago RM, Structural Genomics Consortium (SGC)

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171736 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serine/threonine-protein kinase PRP4 homolog Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 351 amino acids
Theoretical weight: 40.96 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q13523 (Residues: 657-1005; Coverage: 35%)
Gene names: KIAA0536, PRP4, PRP4B, PRP4H, PRP4K, PRPF4K
Sequence domains: Protein kinase domain

Ligands and Environments

3 bound ligands:
Ligand OCJ 4 x OCJ
Ligand EDO 8 x EDO
Ligand PO4 8 x PO4
1 modified residue:
Ligand PTR 4 x PTR

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04-1
Spacegroup: P65
Unit cell:
a: 241.812Å b: 241.812Å c: 50.23Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.193 0.19 0.24
Expression system: Escherichia coli

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