› 6pq5

X-ray diffraction
1.5Å resolution

AGAAAA segment 113-118 from human prion

Released:
DOI: 10.2210/pdb6pq5/pdb
PDB entry 6pq5 coloured by chain, front view.
PDB entry 6pq5 coloured by chain, side view.
PDB entry 6pq5 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Cryo-EM structure of a human prion fibril with a hydrophobic, protease-resistant core.
Glynn C, Sawaya MR, Ge P, Gallagher-Jones M, Short CW, Bowman R, Apostol M, Zhou ZH, Eisenberg DS, Rodriguez JA
Nat Struct Mol Biol 27 417-423 (2020)
PMID: 32284600

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo octamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-137469 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Major prion protein Chains: A, B
Molecule details ›
Chains: A, B
Length: 6 amino acids
Theoretical weight: 430 Da
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P04156 (Residues: 113-118; Coverage: 3%)
Gene names: ALTPRP, PRIP, PRNP, PRP

Ligands and Environments

1 bound ligand:
Ligand MLI 2 x MLI
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID13
Spacegroup: P21
Unit cell:
a: 18.533Å b: 9.508Å c: 17.632Å
α: 90° β: 120.54° γ: 90°
R-values:
R R work R free
0.237 0.234 0.271
Expression system: Not provided

Quick links

Citations

13 review citations

Molecular Chaperones: A Double-Edged Sword in Neurodegenerative Diseases.
Tittelmeier et al. (2020)
12 more

2 mentions without citation

Cryo-EM structure of a human prion fibril with a hydrophobic, protease-resistant core.
Glynn et al. (2020)
1 more