Function and Biology Details
Reaction catalysed:
Preferred amino acids around the cleavage site can be denoted BBBBxHx-|-H, in which B denotes Arg or Lys, H denotes a hydrophobic amino acid, and x is any amino acid. The only known protein substrates are mitogen-activated protein (MAP) kinase kinases.
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
- Bacterial exotoxin B
- Anthrax toxin, lethal/endema factor
- Protective antigen, domain 4
- Clostridial binary toxin B/anthrax toxin PA, domain 3
- Protective antigen, heptamerisation domain
- Protective antigen, heptamerisation domain superfamily
- Protective antigen, Ca-binding domain
- Anthrax toxin lethal factor-like domain
3 more domains
Structure analysis Details
Assembly composition:
hetero octamer (preferred)
Assembly name:
Lethal factor and Protective antigen (preferred)
PDBe Complex ID:
PDB-CPX-146582 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Protective antigen PA-63
Molecule details ›
Chains: A, B, C, D, E, F, G
Length: 568 amino acids
Theoretical weight: 63.52 KDa
Source organism: Bacillus anthracis
Expression system: Escherichia coli BL21(DE3)
UniProt:
Sequence domains:
Length: 568 amino acids
Theoretical weight: 63.52 KDa
Source organism: Bacillus anthracis
Expression system: Escherichia coli BL21(DE3)
UniProt:
- Canonical:
P13423 (Residues: 197-764; Coverage: 77%)
Sequence domains:
Lethal factor
Molecule details ›
Chain: L
Length: 809 amino acids
Theoretical weight: 93.9 KDa
Source organism: Bacillus anthracis
Expression system: Escherichia coli BL21(DE3)
UniProt:
Sequence domains:
Length: 809 amino acids
Theoretical weight: 93.9 KDa
Source organism: Bacillus anthracis
Expression system: Escherichia coli BL21(DE3)
UniProt:
- Canonical: P15917 (Residues: 1-809; Coverage: 100%)
Sequence domains:
