› 6pu0

X-ray diffraction
1.9Å resolution

Pigeon Cryptochrome4 bound to flavin adenine dinucleotide

Released:
DOI: 10.2210/pdb6pu0/pdb
PDB entry 6pu0 coloured by chain, front view.
PDB entry 6pu0 coloured by chain, side view.
PDB entry 6pu0 coloured by chain, top view.
Source organism: Columba livia
Primary publication:
Chemical and structural analysis of a photoactive vertebrate cryptochrome from pigeon.
Zoltowski BD, Chelliah Y, Wickramaratne A, Jarocha L, Karki N, Xu W, Mouritsen H, Hore PJ, Hibbs RE, Green CB, Takahashi JS
Proc Natl Acad Sci U S A 116 19449-19457 (2019)
PMID: 31484780

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-104247 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Photolyase/cryptochrome alpha/beta domain-containing protein Chain: A
Molecule details ›
Chain: A
Length: 502 amino acids
Theoretical weight: 58.18 KDa
Source organism: Columba livia
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: A0A2I0LZR8 (Residues: 1-497; Coverage: 95%)
Gene name: A306_00007326
Sequence domains:

Ligands and Environments

5 bound ligands:
Ligand FAD 1 x FAD
Ligand PGE 1 x PGE
Ligand EDO 1 x EDO
Ligand PEG 4 x PEG
Ligand GOL 1 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-C
Spacegroup: P212121
Unit cell:
a: 54.099Å b: 86.578Å c: 104.267Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.16 0.158 0.195
Expression system: Spodoptera frugiperda

Quick links

Citations

6 review citations

The tail of cryptochromes: an intrinsically disordered cog within the mammalian circadian clock.
Parico et al. (2020)
5 more

8 mentions without citation

Cryptochromes: Photochemical and structural insight into magnetoreception.
Karki et al. (2021)
7 more