› 6puo

Electron Microscopy
3.3Å resolution

Human TRPM2 in the apo state

Released:
DOI: 10.2210/pdb6puo/pdb
PDB entry 6puo coloured by chain, front view.
PDB entry 6puo coloured by chain, side view.
PDB entry 6puo coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Ligand recognition and gating mechanism through three ligand-binding sites of human TRPM2 channel.
Huang Y, Roth B, Lü W, Du J
Elife 8 (2019)
PMID: 31513012
Related structures: EMD-20478

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-131735 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transient receptor potential cation channel subfamily M member 2 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 1512 amino acids
Theoretical weight: 172.28 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: O94759 (Residues: 1-1503; Coverage: 100%)
Gene names: EREG1, KNP3, LTRPC2, TRPC7, TRPM2
Sequence domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.3Å
Relevant EMDB volumes: EMD-20478
Expression system: Homo sapiens

Quick links

Citations

19 review citations

TRPM2 channel-mediated cell death: An important mechanism linking oxidative stress-inducing pathological factors to associated pathological conditions.
Malko et al. (2020)
18 more

8 mentions without citation

A structural overview of the ion channels of the TRPM family.
Huang et al. (2020)
7 more