Function and Biology Details
Reactions catalysed:
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1)
3'-end directed exonucleolytic cleavage of viral RNA-DNA hybrid
Endohydrolysis of RNA in RNA/DNA hybrids. Three different cleavage modes: 1. sequence-specific internal cleavage of RNA. Human immunodeficiency virus type 1 and Moloney murine leukemia virus enzymes prefer to cleave the RNA strand one nucleotide away from the RNA-DNA junction. 2. RNA 5'-end directed cleavage 13-19 nucleotides from the RNA end. 3. DNA 3'-end directed cleavage 15-20 nucleotides away from the primer terminus.
Specific for a P1 residue that is hydrophobic, and P1' variable, but often Pro.
Biochemical function:
Biological process:
Cellular component:
Structure analysis Details
Assembly composition:
hetero dodecamer (preferred)
Assembly name:
DNA-binding protein 7d, Integrase and DNA (preferred)
PDBe Complex ID:
PDB-CPX-120466 (preferred)
Entry contents:
1 distinct polypeptide molecule
2 distinct DNA molecules
2 distinct DNA molecules
Macromolecules (3 distinct):
DNA-binding protein 7d; Integrase
Molecule details ›
Chains: A, B, C, D
Length: 383 amino acids
Theoretical weight: 42.32 KDa
Source organisms: Expression system: Escherichia coli
UniProt:
Sequence domains:
Length: 383 amino acids
Theoretical weight: 42.32 KDa
Source organisms: Expression system: Escherichia coli
UniProt:
- Canonical:
P39476 (Residues: 1-64; Coverage: 100%) - Canonical: P12497 (Residues: 1148-1435; Coverage: 20%)
Sequence domains:
