› 6pws

X-ray diffraction
1Å resolution

Crystal structure of the cow C-type carbohydrate-recognition domain of CD23 in the presence of alpha-methyl mannoside

Released:
DOI: 10.2210/pdb6pws/pdb
PDB entry 6pws coloured by chain, front view.
PDB entry 6pws coloured by chain, side view.
PDB entry 6pws coloured by chain, top view.
Source organism: Bos taurus
Primary publication:
CD23 is a glycan-binding receptor in some mammalian species.
Jégouzo SAF, Feinberg H, Morrison AG, Holder A, May A, Huang Z, Jiang L, Lasanajak Y, Smith DF, Werling D, Drickamer K, Weis WI, Taylor ME
J Biol Chem 294 14845-14859 (2019)
PMID: 31488546

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-122750 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
C-type lectin domain-containing protein Chain: A
Molecule details ›
Chain: A
Length: 134 amino acids
Theoretical weight: 15.35 KDa
Source organism: Bos taurus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: E1BIQ4 (Residues: 161-294; Coverage: 46%)
Gene name: FCER2
Sequence domains: Lectin C-type domain

Ligands and Environments

2 bound ligands:
Ligand CA 2 x CA
Ligand MMA 1 x MMA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL12-2
Spacegroup: P212121
Unit cell:
a: 38.553Å b: 45.915Å c: 69.273Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.115 0.115 0.128
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

5 review citations

The role of CD23 in the regulation of allergic responses.
Engeroff et al. (2021)
4 more

1 mention without citation

CD23 is a glycan-binding receptor in some mammalian species.
Jégouzo et al. (2019)