› 6px0

X-ray diffraction
1.55Å resolution

Crystal structure of the TPR domain of human aryl hydrocarbon receptor-interacting protein-like 1 (AIPL1)

Released:
DOI: 10.2210/pdb6px0/pdb
PDB entry 6px0 coloured by chain, front view.
PDB entry 6px0 coloured by chain, side view.
PDB entry 6px0 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Interaction of the tetratricopeptide repeat domain of aryl hydrocarbon receptor-interacting protein-like 1 with the regulatory Pγ subunit of phosphodiesterase 6.
Yadav RP, Boyd K, Yu L, Artemyev NO
J Biol Chem 294 15795-15807 (2019)
PMID: 31488544

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-192770 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Aryl-hydrocarbon-interacting protein-like 1 Chain: A
Molecule details ›
Chain: A
Length: 155 amino acids
Theoretical weight: 18.46 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q9NZN9 (Residues: 171-316; Coverage: 38%)
Gene names: AIPL1, AIPL2

Ligands and Environments

4 bound ligands:
Ligand PEG 2 x PEG
Ligand PG4 1 x PG4
Ligand BME 2 x BME
Ligand EDO 3 x EDO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 4.2.2
Spacegroup: P21
Unit cell:
a: 37.75Å b: 44.17Å c: 52.53Å
α: 90° β: 100.956° γ: 90°
R-values:
R R work R free
0.19 0.188 0.22
Expression system: Escherichia coli BL21

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Citations

4 review citations

Compartmentalization of Photoreceptor Sensory Cilia.
Barnes et al. (2021)
3 more

2 mentions without citation

The Role of Hsp90 in Retinal Proteostasis and Disease.
Ziaka et al. (2022)
1 more