6pxr

X-ray diffraction
1.56Å resolution

Anti-TAU BIIB092 FAB with TAU peptide

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-207558 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Ig-like domain-containing protein Chain: L
Molecule details ›
Chain: L
Length: 219 amino acids
Theoretical weight: 24.11 KDa
Source organism: Mus musculus
Expression system: Cricetulus griseus
UniProt:
  • Canonical: A2NHM3 (Residues: 1-219; Coverage: 100%)
Gene names: Igk-C, Igkc
Sequence domains:
gosuranemab Fab, heavy chain Chain: H
Molecule details ›
Chain: H
Length: 224 amino acids
Theoretical weight: 23.91 KDa
Source organism: Mus musculus
Expression system: Cricetulus griseus
Microtubule-associated protein tau Chain: A
Molecule details ›
Chain: A
Length: 8 amino acids
Theoretical weight: 753 Da
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P10636 (Residues: 15-22; Coverage: 1%)
Gene names: MAPT, MAPTL, MTBT1, TAU

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 31-ID
Spacegroup: P1
Unit cell:
a: 42.745Å b: 48.952Å c: 58.653Å
α: 85.25° β: 83.12° γ: 70.72°
R-values:
R R work R free
0.23 0.228 0.268
Expression systems:
  • Cricetulus griseus
  • Homo sapiens