› 6py2

X-ray diffraction
2.83Å resolution

HLA-TCR complex

Released:
DOI: 10.2210/pdb6py2/pdb
Model geometry
Data not analysed
Fit model/data
Data not analysed
PDB entry 6py2 coloured by chain, front view.
PDB entry 6py2 coloured by chain, side view.
PDB entry 6py2 coloured by chain, top view.
Source organisms:
Primary publication:
A molecular basis for the T cell response in HLA-DQ2.2 mediated celiac disease.
Ting YT, Dahal-Koirala S, Kim HSK, Qiao SW, Neumann RS, Lundin KEA, Petersen J, Reid HH, Sollid LM, Rossjohn J
Proc Natl Acad Sci U S A 117 3063-3073 (2020)
PMID: 31974305

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero pentamer (preferred)
PDBe Complex ID:
PDB-CPX-102772 (preferred)
Entry contents:
5 distinct polypeptide molecules
Macromolecules (5 distinct):
Ig-like domain-containing protein Chain: A
Molecule details ›
Chain: A
Length: 254 amino acids
Theoretical weight: 27.96 KDa
Source organism: Homo sapiens
Expression system: Baculovirus expression vector pFastBac1-HM
UniProt:
  • Canonical: Q08AS3 (Residues: 1-254; Coverage: 100%)
Gene name: HLA-DQA1
Sequence domains:
Ig-like domain-containing protein Chain: B
Molecule details ›
Chain: B
Length: 261 amino acids
Theoretical weight: 29.71 KDa
Source organism: Homo sapiens
Expression system: Baculovirus expression vector pFastBac1-HM
UniProt:
  • Canonical: A0A0U5IHY9 (Residues: 1-261; Coverage: 100%)
Gene name: HLA-DQB1
Sequence domains:
Glutenin, low molecular weight subunit PTDUCD1 Chain: C
Ig-like domain-containing protein Chain: D
Ig-like domain-containing protein Chain: E

Ligands and Environments

2 bound ligands:
Ligand NAG 3 x NAG
Ligand GOL 2 x GOL
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: AUSTRALIAN SYNCHROTRON BEAMLINE MX2
Spacegroup: C2221
Unit cell:
a: 75.28Å b: 275.14Å c: 141.55Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.217 0.216 0.244
Expression systems:
  • Baculovirus expression vector pFastBac1-HM
  • Not provided
  • Escherichia coli BL21

Quick links

Citations

13 review citations

Interplay Between Gluten, HLA, Innate and Adaptive Immunity Orchestrates the Development of Coeliac Disease.
Voisine et al. (2021)
12 more

4 mentions without citation

The Many Faces of CD4+ T Cells: Immunological and Structural Characteristics.
Chatzileontiadou et al. (2020)
3 more