› 6pyj

X-ray diffraction
1.44Å resolution

Crystal Structure of HLA-B*2705 in complex with LRN, a self-peptide

Released:
DOI: 10.2210/pdb6pyj/pdb
PDB entry 6pyj coloured by chain, front view.
PDB entry 6pyj coloured by chain, side view.
PDB entry 6pyj coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Allelic association with ankylosing spondylitis fails to correlate with human leukocyte antigen B27 homodimer formation.
Lim Kam Sian TCC, Indumathy S, Halim H, Greule A, Cryle MJ, Bowness P, Rossjohn J, Gras S, Purcell AW, Schittenhelm RB
J Biol Chem 294 20185-20195 (2019)
PMID: 31740583

Function and Biology Details

Reaction catalysed: 
(1a) 2 farnesyl diphosphate = diphosphate + presqualene diphosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-105307 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Ig-like domain-containing protein Chain: A
Molecule details ›
Chain: A
Length: 276 amino acids
Theoretical weight: 31.93 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: A0A583ZBQ2 (Residues: 25-300; Coverage: 82%)
Sequence domains:
Beta-2-microglobulin Chain: B
Molecule details ›
Chain: B
Length: 99 amino acids
Theoretical weight: 11.75 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P61769 (Residues: 21-119; Coverage: 100%)
Gene names: B2M, CDABP0092, HDCMA22P
Sequence domains: Immunoglobulin C1-set domain
Squalene synthase Chain: C
Molecule details ›
Chain: C
Length: 9 amino acids
Theoretical weight: 1.13 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P37268 (Residues: 280-288; Coverage: 2%)
Gene name: FDFT1

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: AUSTRALIAN SYNCHROTRON BEAMLINE MX2
Spacegroup: P212121
Unit cell:
a: 50.78Å b: 82.704Å c: 104.979Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.203 0.202 0.22
Expression systems:
  • Escherichia coli BL21
  • Not provided

Quick links

Citations

6 review citations

Understanding the Pathogenesis of Spondyloarthritis.
Sharip et al. (2020)
5 more

3 mentions without citation

Novel In Silico mRNA vaccine design exploiting proteins of M. tuberculosis that modulates host immune responses by inducing epigenetic modifications.
Al Tbeishat H. (2022)
2 more