› 6q1g

X-ray diffraction
1.75Å resolution

Human antibody H1244 of the human antibody lineage 652

Released:
DOI: 10.2210/pdb6q1g/pdb
Model geometry
Fit model/data
PDB entry 6q1g coloured by chain, front view.
PDB entry 6q1g coloured by chain, side view.
PDB entry 6q1g coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Affinity maturation in a human humoral response to influenza hemagglutinin.
McCarthy KR, Raymond DD, Do KT, Schmidt AG, Harrison SC
OpenAccess logo Proc Natl Acad Sci U S A (2019)
PMID: 31843892

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-214166 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
H1244 Fab lambda chain Chain: L
Molecule details ›
Chain: L
Length: 217 amino acids
Theoretical weight: 23.07 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
H1244 Fab heavy chain Chain: H
Molecule details ›
Chain: H
Length: 243 amino acids
Theoretical weight: 25.87 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens

Ligands and Environments

1 bound ligand:
Ligand GOL 3 x GOL
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: ALS BEAMLINE 8.2.2
Spacegroup: P212121
Unit cell:
a: 67.14Å b: 67.47Å c: 95.69Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.181 0.18 0.206
Expression system: Homo sapiens

Quick links

Citations

5 review citations

B Cell Responses against Influenza Viruses: Short-Lived Humoral Immunity against a Life-Long Threat.
Guthmiller et al. (2021)
4 more

1 mention without citation

Affinity maturation in a human humoral response to influenza hemagglutinin.
McCarthy et al. (2019)