› 6q91

X-ray diffraction
2.4Å resolution

Structure of human galactokinase 1 bound with 5-Chloro-N-isobutyl-2-methoxybenzamide

Released:
DOI: 10.2210/pdb6q91/pdb
PDB entry 6q91 coloured by chain, front view.
PDB entry 6q91 coloured by chain, side view.
PDB entry 6q91 coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Mackinnon SR, Bezerra GA, Zhang M, Foster W, Krojer T, Brandao-Neto J, Douangamath A, Arrowsmith C, Edwards A, Bountra C, Brennan P, Lai K, Yue WW

Function and Biology Details

Reaction catalysed: 
ATP + alpha-D-galactose = ADP + alpha-D-galactose 1-phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-156360 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Galactokinase Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 392 amino acids
Theoretical weight: 42.21 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P51570 (Residues: 2-392; Coverage: 100%)
Gene names: GALK, GALK1
Sequence domains:
Structure domains:

Ligands and Environments

3 bound ligands:
Ligand GAL 3 x GAL
Ligand HFK 3 x HFK
Ligand HR8 4 x HR8
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04-1
Spacegroup: P21
Unit cell:
a: 73.323Å b: 114.959Å c: 120.918Å
α: 90° β: 100.79° γ: 90°
R-values:
R R work R free
0.219 0.216 0.286
Expression system: Escherichia coli

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