› 6q9s

X-ray diffraction
2.4Å resolution

HDMX (14-111; C17S) COMPLEXED WITH COMPOUND 14 AT 2.4A: Structural states of Hdm2 and HdmX: X-ray elucidation of adaptations and binding interactions for different chemical compound classes

Released:
DOI: 10.2210/pdb6q9s/pdb
PDB entry 6q9s coloured by chain, front view.
PDB entry 6q9s coloured by chain, side view.
PDB entry 6q9s coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural States of Hdm2 and HdmX: X-ray Elucidation of Adaptations and Binding Interactions for Different Chemical Compound Classes.
Kallen J, Izaac A, Chau S, Wirth E, Schoepfer J, Mah R, Schlapbach A, Stutz S, Vaupel A, Guagnano V, Masuya K, Stachyra TM, Salem B, Chene P, Gessier F, Holzer P, Furet P
ChemMedChem 14 1305-1314 (2019)
PMID: 31066983

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-127312 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Protein Mdm4 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 100 amino acids
Theoretical weight: 11.19 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: O15151 (Residues: 14-111; Coverage: 20%)
Gene names: MDM4, MDMX
Structure domains: SWIB/MDM2 domain

Ligands and Environments

4 bound ligands:
Ligand HRN 3 x HRN
Ligand O4B 13 x O4B
Ligand SO4 5 x SO4
Ligand NA 3 x NA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: P6422
Unit cell:
a: 93.581Å b: 93.581Å c: 198.467Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.25 0.249 0.268
Expression system: Escherichia coli BL21

Quick links

Citations

1 review citation

Proteasomal Degradation of Zn-Dependent Hdacs: The E3-Ligases Implicated and the Designed Protacs That Enable Degradation.
Márquez-Cantudo et al. (2021)
4 other articles

1 mention without citation

Therapeutic Strategies to Activate p53.
Aguilar et al. (2022)