› 6q9u

X-ray diffraction
2.4Å resolution

HDMX (14-111; C17S) COMPLEXED WITH COMPOUND 12 AT 2.4A; Structural states of Hdm2 and HdmX: X-ray elucidation of adaptations and binding interactions for different chemical compound classes

Released:
DOI: 10.2210/pdb6q9u/pdb
PDB entry 6q9u coloured by chain, front view.
PDB entry 6q9u coloured by chain, side view.
PDB entry 6q9u coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural States of Hdm2 and HdmX: X-ray Elucidation of Adaptations and Binding Interactions for Different Chemical Compound Classes.
Kallen J, Izaac A, Chau S, Wirth E, Schoepfer J, Mah R, Schlapbach A, Stutz S, Vaupel A, Guagnano V, Masuya K, Stachyra TM, Salem B, Chene P, Gessier F, Holzer P, Furet P
ChemMedChem 14 1305-1314 (2019)
PMID: 31066983

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-127312 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Protein Mdm4 Chain: A
Molecule details ›
Chain: A
Length: 100 amino acids
Theoretical weight: 11.19 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: O15151 (Residues: 14-111; Coverage: 20%)
Gene names: MDM4, MDMX
Structure domains: SWIB/MDM2 domain

Ligands and Environments

3 bound ligands:
Ligand HRE 1 x HRE
Ligand O4B 1 x O4B
Ligand CL 1 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: P41
Unit cell:
a: 45.403Å b: 45.403Å c: 55.825Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.208 0.205 0.265
Expression system: Escherichia coli BL21

Quick links

Citations

2 review citations

Therapeutic Strategies to Activate p53.
Aguilar et al. (2022)
1 more