› 6qav

X-ray diffraction
2.05Å resolution

Crystal structure of ULK2 in complexed with MRT68921

Released:
DOI: 10.2210/pdb6qav/pdb
PDB entry 6qav coloured by chain, front view.
PDB entry 6qav coloured by chain, side view.
PDB entry 6qav coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Conservation of structure, function and inhibitor binding in UNC-51-like kinase 1 and 2 (ULK1/2).
Chaikuad A, Koschade SE, Stolz A, Zivkovic K, Pohl C, Shaid S, Ren H, Lambert LJ, Cosford NDP, Brandts CH, Knapp S
Biochem J 476 875-887 (2019)
PMID: 30782972

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-184950 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serine/threonine-protein kinase ULK2 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 280 amino acids
Theoretical weight: 31.77 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q8IYT8 (Residues: 1-276; Coverage: 27%)
Gene names: KIAA0623, ULK2
Sequence domains: Protein kinase domain

Ligands and Environments

4 bound ligands:
Ligand HVH 4 x HVH
Ligand EDO 15 x EDO
Ligand NA 1 x NA
Ligand GOL 2 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06DA
Spacegroup: P21
Unit cell:
a: 74.648Å b: 69.05Å c: 107.71Å
α: 90° β: 97.93° γ: 90°
R-values:
R R work R free
0.197 0.195 0.231
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

9 review citations

Targeting Autophagy in Cancer: Recent Advances and Future Directions.
Amaravadi et al. (2019)
8 more

3 mentions without citation

Small Molecule Inhibitors for Unc-51-like Autophagy-Activating Kinase Targeting Autophagy in Cancer.
Karmacharya et al. (2023)
2 more