› 6qb9

X-ray diffraction
1.85Å resolution

Structure of an anti-Mcl1 scFv

Released:
DOI: 10.2210/pdb6qb9/pdb
Model geometry
Fit model/data
PDB entry 6qb9 coloured by chain, front view.
PDB entry 6qb9 coloured by chain, side view.
PDB entry 6qb9 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Antibody fragments structurally enable a drug-discovery campaign on the cancer target Mcl-1.
Luptak J, Bista M, Fisher D, Flavell L, Gao N, Wickson K, Kazmirski SL, Howard T, Rawlins PB, Hargreaves D
OpenAccess logo Acta Crystallogr D Struct Biol 75 1003-1014 (2019)
PMID: 31692474

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-214169 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
scFv55 Chains: A, X
Molecule details ›
Chains: A, X
Length: 255 amino acids
Theoretical weight: 26.43 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus

Ligands and Environments

1 bound ligand:
Ligand TLA 2 x TLA
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: DIAMOND BEAMLINE I02
Spacegroup: C2
Unit cell:
a: 77.88Å b: 63.03Å c: 101.7Å
α: 90° β: 109.96° γ: 90°
R-values:
R R work R free
0.202 0.2 0.239
Expression system: Cricetulus griseus

Quick links

Citations

2 citation in other articles

Structural basis of the specificity and interaction mechanism of Bmf binding to pro-survival Bcl-2 family proteins.
Wang et al. (2023)
1 more

1 mention without citation

Antibody fragments structurally enable a drug-discovery campaign on the cancer target Mcl-1.
Luptak et al. (2019)