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› 6qce

X-ray diffraction
1.9Å resolution

Human Sirt6 in complex with ADP-ribose and the activator isoquercetin

Released:
DOI: 10.2210/pdb6qce/pdb
Model geometry
Fit model/data
PDB entry 6qce coloured by chain, front view.
PDB entry 6qce coloured by chain, side view.
PDB entry 6qce coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis for the activation and inhibition of Sirtuin 6 by quercetin and its derivatives.
You W, Zheng W, Weiss S, Chua KF, Steegborn C
OpenAccess logo Sci Rep 9 19176 (2019)
PMID: 31844103

Function and Biology Details

Reaction catalysed: 
N(6)-acetyl-L-lysyl-[protein] + NAD(+) + H2O = 2''-O-acetyl-ADP-D-ribose+ nicotinamide + L-lysyl-[protein].
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-185425 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
NAD-dependent protein deacylase sirtuin-6 Chains: A, B
Molecule details ›
Chains: A, B
Length: 302 amino acids
Theoretical weight: 33.63 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8N6T7 (Residues: 13-308; Coverage: 83%)
Gene names: SIR2L6, SIRT6
Sequence domains: Sir2 family

Ligands and Environments

5 bound ligands:
Ligand AR6 2 x AR6
Ligand ZN 2 x ZN
Ligand SO4 9 x SO4
Ligand HW2 2 x HW2
Ligand EDO 4 x EDO
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: BESSY BEAMLINE 14.2
Spacegroup: P63
Unit cell:
a: 91.413Å b: 91.413Å c: 144.158Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.153 0.152 0.187
Expression system: Escherichia coli

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Citations

17 review citations

Emerging roles of SIRT6 in human diseases and its modulators.
Liu et al. (2021)
16 more