› 6qe9

X-ray diffraction
2.03Å resolution

The X-ray structure of the adduct formed in the reaction between bovine pancreatic ribonuclease and complex I, a pentacoordinate Pt(II) compound containing 2,9-dimethyl-1,10-phenanthroline, dimethylfumarate, methyl and iodine as ligands

Released:
DOI: 10.2210/pdb6qe9/pdb
PDB entry 6qe9 coloured by chain, front view.
PDB entry 6qe9 coloured by chain, side view.
PDB entry 6qe9 coloured by chain, top view.
Source organism: Bos taurus
Primary publication:
Reaction with Proteins of a Five-Coordinate Platinum(II) Compound.
Ferraro G, Marzo T, Cucciolito ME, Ruffo F, Messori L, Merlino A
Int J Mol Sci 20 (2019)
PMID: 30691130

Function and Biology Details

Reaction catalysed: 
(1a) an (RNA) containing cytidine = an (RNA)-3'-cytidine-2',3'-cyclophosphate + a 5'-hydroxy-ribonucleotide-3'-(RNA)
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-158390 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ribonuclease pancreatic Chains: A, B
Molecule details ›
Chains: A, B
Length: 124 amino acids
Theoretical weight: 13.71 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P61823 (Residues: 27-150; Coverage: 100%)
Gene names: RNASE1, RNS1
Sequence domains: Pancreatic ribonuclease
Structure domains: Ribonuclease A-like domain

Ligands and Environments

2 bound ligands:
Ligand SO4 1 x SO4
Ligand J9H 2 x J9H
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU
Spacegroup: C2
Unit cell:
a: 99.005Å b: 30.655Å c: 68.68Å
α: 90° β: 92.97° γ: 90°
R-values:
R R work R free
0.18 0.177 0.254

Quick links

Citations

3 citation in other articles

Reactions with Proteins of Three Novel Anticancer Platinum(II) Complexes Bearing N-Heterocyclic Ligands.
Sacco et al. (2021)
2 more

2 mentions without citation

Structures of Respiratory Supercomplex I+III2 Reveal Functional and Conformational Crosstalk.
Letts et al. (2019)
1 more