› 6qf5

X-ray diffraction
3.7Å resolution

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-154260 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Aquaporin-2 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 242 amino acids
Theoretical weight: 25.24 KDa
Source organism: Homo sapiens
Expression system: Komagataella phaffii GS115
UniProt:
  • Canonical: P41181 (Residues: 3-242; Coverage: 89%)
Gene name: AQP2
Sequence domains: Major intrinsic protein

Ligands and Environments

1 bound ligand:
Ligand CD 3 x CD
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLAC LCLS BEAMLINE MFX
Spacegroup: P42
Unit cell:
a: 122.2Å b: 122.2Å c: 94.14Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.287 0.282 0.336
Expression system: Komagataella phaffii GS115

Quick links

Citations

2 review citations

Best practices for time-resolved serial synchrotron crystallography.
Schulz et al. (2022)
1 more

2 mentions without citation

Aquaporin Gating: A New Twist to Unravel Permeation through Water Channels.
Ozu et al. (2022)
1 more