› 6qh4

X-ray diffraction
1.92Å resolution

Crystal structure of human Methylmalonyl-CoA epimerase (MCEE) p.Arg143Cys variant

Released:
DOI: 10.2210/pdb6qh4/pdb
PDB entry 6qh4 coloured by chain, front view.
PDB entry 6qh4 coloured by chain, side view.
PDB entry 6qh4 coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Bailey HJ, Chaikuid A, Krysztofinska E, Froese DS, Sorrell FJ, Diaz-Saez L, Kennedy E, Edwards AM, Bountra C, Yue WW

Function and Biology Details

Reaction catalysed: 
(R)-methylmalonyl-CoA = (S)-methylmalonyl-CoA
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-188667 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Methylmalonyl-CoA epimerase, mitochondrial Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 155 amino acids
Theoretical weight: 16.8 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli K-12
UniProt:
  • Canonical: Q96PE7 (Residues: 45-176; Coverage: 75%)
Gene name: MCEE
Sequence domains: Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
Structure domains: 2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1

Ligands and Environments

1 bound ligand:
Ligand CO 4 x CO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04
Spacegroup: P21
Unit cell:
a: 53.162Å b: 66.99Å c: 77.125Å
α: 90° β: 90.02° γ: 90°
R-values:
R R work R free
0.23 0.228 0.276
Expression system: Escherichia coli K-12

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