› 6qje

X-ray diffraction
2.4Å resolution

Structure of human galactokinase 1 bound with 4-{[2-(Methylsulfonyl)-1H-imidazol-1-yl]methyl}-1,3-thiazole

Released:
DOI: 10.2210/pdb6qje/pdb
PDB entry 6qje coloured by chain, front view.
PDB entry 6qje coloured by chain, side view.
PDB entry 6qje coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Mackinnon SR, Bezerra GA, Zhang M, Foster W, Krojer T, Brandao-Neto J, Douangamath A, Arrowsmith C, Edwards A, Bountra C, Brennan P, Lai K, Yue WW

Function and Biology Details

Reaction catalysed: 
ATP + alpha-D-galactose = ADP + alpha-D-galactose 1-phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-156360 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Galactokinase Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 392 amino acids
Theoretical weight: 42.21 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P51570 (Residues: 2-392; Coverage: 100%)
Gene names: GALK, GALK1
Sequence domains:
Structure domains:

Ligands and Environments

4 bound ligands:
Ligand GAL 3 x GAL
Ligand HFK 3 x HFK
Ligand J4Q 3 x J4Q
Ligand SO4 1 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04-1
Spacegroup: P21
Unit cell:
a: 73.703Å b: 114.873Å c: 121.044Å
α: 90° β: 100.56° γ: 90°
R-values:
R R work R free
0.22 0.217 0.269
Expression system: Escherichia coli BL21(DE3)

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