› 6qm7

Electron Microscopy
2.8Å resolution

Function and Biology Details

Reaction catalysed: 
Cleavage of peptide bonds with very broad specificity.
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero 28-mer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-104710 (preferred)
Entry contents:
14 distinct polypeptide molecules
Macromolecules (14 distinct):
Proteasome subunit alpha type Chains: A, O
Molecule details ›
Chains: A, O
Length: 250 amino acids
Theoretical weight: 27.18 KDa
Source organism: Leishmania tarentolae
UniProt:
  • Canonical: A0A6L0XSJ0 (Residues: 1-250; Coverage: 100%)
Gene name: LINJ_35_4910
Sequence domains:
Structure domains: Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
Proteasome subunit alpha type Chains: B, P
Molecule details ›
Chains: B, P
Length: 231 amino acids
Theoretical weight: 25.18 KDa
Source organism: Leishmania tarentolae
UniProt:
  • Canonical: Q9GNZ8 (Residues: 1-231; Coverage: 100%)
Gene name: LINJ_21_2070
Sequence domains:
Proteasome subunit alpha type Chains: C, Q
Molecule details ›
Chains: C, Q
Length: 285 amino acids
Theoretical weight: 32.32 KDa
Source organism: Leishmania tarentolae
UniProt:
  • Canonical: A4HVX3 (Residues: 1-285; Coverage: 100%)
Gene name: LINJ_14_0310
Sequence domains:
Proteasome subunit alpha type Chains: D, R
Molecule details ›
Chains: D, R
Length: 248 amino acids
Theoretical weight: 27.82 KDa
Source organism: Leishmania tarentolae
UniProt:
  • Canonical: A4HUT6 (Residues: 1-238, 239-247; Coverage: 100%)
Gene name: LINJ_11_0240
Sequence domains:
Structure domains: Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
Proteasome subunit alpha type Chains: E, S
Molecule details ›
Chains: E, S
Length: 344 amino acids
Theoretical weight: 38.31 KDa
Source organism: Leishmania tarentolae
UniProt:
  • Canonical: A4HZI9 (Residues: 1-244; Coverage: 100%)
Gene name: LINJ_21_2200
Sequence domains:
Structure domains: Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
Proteasome subunit alpha type Chains: F, T
Molecule details ›
Chains: F, T
Length: 428 amino acids
Theoretical weight: 47.98 KDa
Source organism: Leishmania tarentolae
UniProt:
  • Canonical: A4IDD0 (Residues: 1-264; Coverage: 100%)
Gene name: LINJ_36_1670
Sequence domains:
Structure domains: Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
Proteasome alpha-type subunits domain-containing protein Chains: G, U
Molecule details ›
Chains: G, U
Length: 238 amino acids
Theoretical weight: 25.59 KDa
Source organism: Leishmania tarentolae
UniProt:
  • Canonical: A4I357 (Residues: 1-238; Coverage: 100%)
Gene name: LINJ_27_0190
Sequence domains:
Structure domains: Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
Proteasome subunit beta Chains: H, V
Molecule details ›
Chains: H, V
Length: 283 amino acids
Theoretical weight: 30.28 KDa
Source organism: Leishmania tarentolae
UniProt:
  • Canonical: A4HV47 (Residues: 1-283; Coverage: 100%)
Gene name: LINJ.12.0003
Sequence domains: Proteasome subunit
Proteasome subunit beta Chains: I, W
Molecule details ›
Chains: I, W
Length: 254 amino acids
Theoretical weight: 27.6 KDa
Source organism: Leishmania tarentolae
UniProt:
  • Canonical: A4HN55 (Residues: 1-253; Coverage: 100%)
Gene name: LBRM_34_3820
Sequence domains: Proteasome subunit
Structure domains: Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
Proteasome subunit beta Chains: J, X
Molecule details ›
Chains: J, X
Length: 205 amino acids
Theoretical weight: 22.47 KDa
Source organism: Leishmania tarentolae
UniProt:
  • Canonical: A4I384 (Residues: 1-205; Coverage: 100%)
Gene name: LINJ_28_0110
Sequence domains: Proteasome subunit
Structure domains: Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
Proteasome subunit beta Chains: K, Y
Molecule details ›
Chains: K, Y
Length: 206 amino acids
Theoretical weight: 23.07 KDa
Source organism: Leishmania tarentolae
UniProt:
  • Canonical: A4ICV5 (Residues: 1-206; Coverage: 100%)
Gene name: LINJ_36_0340
Sequence domains: Proteasome subunit
Structure domains: Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
Proteasome subunit beta Chains: L, Z
Molecule details ›
Chains: L, Z
Length: 302 amino acids
Theoretical weight: 33.7 KDa
Source organism: Leishmania tarentolae
UniProt:
  • Canonical: A4IDD6 (Residues: 1-302; Coverage: 100%)
Gene name: LINJ_36_1730
Sequence domains: Proteasome subunit
Structure domains: Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
Proteasome subunit beta Chains: M, a
Molecule details ›
Chains: M, a
Length: 339 amino acids
Theoretical weight: 37.68 KDa
Source organism: Leishmania tarentolae
UniProt:
  • Canonical: A4HSQ5 (Residues: 1-247; Coverage: 100%)
Gene name: LINJ_06_0140
Sequence domains: Proteasome subunit
Structure domains: Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
Proteasome subunit beta Chains: N, b
Molecule details ›
Chains: N, b
Length: 220 amino acids
Theoretical weight: 24.74 KDa
Source organism: Leishmania tarentolae
UniProt:
  • Canonical: A0A381MU64 (Residues: 1-220; Coverage: 100%)
Gene name: LinJ_34_4390
Sequence domains: Proteasome subunit
Structure domains: Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1

Ligands and Environments

1 bound ligand:
Ligand J6E 2 x J6E
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.8Å
Relevant EMDB volumes: EMD-4590

Quick links

Citations

17 review citations

An Overview on the Therapeutics of Neglected Infectious Diseases-Leishmaniasis and Chagas Diseases.
J et al. (2021)
16 more

9 mentions without citation

Ubiquitination and the Proteasome as Drug Targets in Trypanosomatid Diseases.
Bijlmakers MJ. (2020)
8 more