Function and Biology Details
Reaction catalysed:
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1)
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
- Influenza RNA-dependent RNA polymerase subunit PB1
- PB2, C-terminal
- Influenza RNA-dependent RNA polymerase subunit PB2
- RNA-directed RNA polymerase, negative-strand RNA virus
- Influenza RNA-dependent RNA polymerase subunit PA
- Influenza RNA-dependent RNA polymerase subunit PA, endonuclease domain
- Polymerase acidic protein
Structure analysis Details
Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-112588 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Polymerase acidic protein
Molecule details ›
Chains: A, D, G, J
Length: 716 amino acids
Theoretical weight: 82.71 KDa
Source organism: Influenza A virus (A/duck/Fujian/01/2002(H5N1))
Expression system: Spodoptera frugiperda
UniProt:
Sequence domains: Influenza RNA-dependent RNA polymerase subunit PA
Length: 716 amino acids
Theoretical weight: 82.71 KDa
Source organism: Influenza A virus (A/duck/Fujian/01/2002(H5N1))
Expression system: Spodoptera frugiperda
UniProt:
- Canonical:
D3YNB8 (Residues: 1-716; Coverage: 100%)
Sequence domains: Influenza RNA-dependent RNA polymerase subunit PA
RNA-directed RNA polymerase catalytic subunit
Molecule details ›
Chains: B, E, H, K
Length: 757 amino acids
Theoretical weight: 86.55 KDa
Source organism: Influenza A virus (A/duck/Fujian/01/2002(H5N1))
Expression system: Spodoptera frugiperda
UniProt:
Sequence domains: Influenza RNA-dependent RNA polymerase subunit PB1
Length: 757 amino acids
Theoretical weight: 86.55 KDa
Source organism: Influenza A virus (A/duck/Fujian/01/2002(H5N1))
Expression system: Spodoptera frugiperda
UniProt:
- Canonical: D3YNB6 (Residues: 1-757; Coverage: 100%)
Sequence domains: Influenza RNA-dependent RNA polymerase subunit PB1
Polymerase basic protein 2
Molecule details ›
Chains: C, F, I, L
Length: 765 amino acids
Theoretical weight: 86.82 KDa
Source organism: Influenza A virus (A/duck/Fujian/01/2002(H5N1))
Expression system: Spodoptera frugiperda
UniProt:
Sequence domains:
Length: 765 amino acids
Theoretical weight: 86.82 KDa
Source organism: Influenza A virus (A/duck/Fujian/01/2002(H5N1))
Expression system: Spodoptera frugiperda
UniProt:
- Canonical: D3YNB5 (Residues: 1-759; Coverage: 100%)
Sequence domains:
- Influenza RNA polymerase PB2 N-terminal region
- Influenza RNA polymerase PB2 second domain
- Influenza RNA polymerase PB2 middle domain
- Influenza RNA polymerase PB2 helical domain
- Influenza RNA polymerase PB2 CAP binding domain
- Influenza RNA polymerase PB2 6th domain
- Influenza RNA polymerase PB2 C-terminal domain
Ligands and Environments
No bound ligands
No modified residues
Experiments and Validation Details
X-ray source:
DIAMOND BEAMLINE I04
Spacegroup:
C2
Expression system: Spodoptera frugiperda
