› 6qs5

X-ray diffraction
1.96Å resolution

Crystal Structure of maize CK2 in complex with tyrphostin AG99

Released:
DOI: 10.2210/pdb6qs5/pdb
PDB entry 6qs5 coloured by chain, front view.
PDB entry 6qs5 coloured by chain, side view.
PDB entry 6qs5 coloured by chain, top view.
Source organism: Zea mays
Primary publication:
Inhibition of protein kinase CK2 by flavonoids and tyrphostins. A structural insight.
Lolli G, Cozza G, Mazzorana M, Tibaldi E, Cesaro L, Donella-Deana A, Meggio F, Venerando A, Franchin C, Sarno S, Battistutta R, Pinna LA
Biochemistry 51 6097-107 (2012)
PMID: 22794353

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-151243 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Casein kinase II subunit alpha Chain: A
Molecule details ›
Chain: A
Length: 325 amino acids
Theoretical weight: 38.47 KDa
Source organism: Zea mays
Expression system: Escherichia coli
UniProt:
  • Canonical: P28523 (Residues: 2-326; Coverage: 98%)
Gene name: ACK2
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand JGB 1 x JGB
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ELETTRA BEAMLINE 5.2R
Spacegroup: C2
Unit cell:
a: 142.97Å b: 59.55Å c: 46.35Å
α: 90° β: 103.81° γ: 90°
R-values:
R R work R free
0.186 0.185 0.219
Expression system: Escherichia coli

Quick links

Citations

21 review citations

Secreted protein kinases.
Tagliabracci et al. (2013)
20 more