› 6qvw

Solution NMR

Solution structure of the free FOXO1 DNA binding domain

Released:
DOI: 10.2210/pdb6qvw/pdb
PDB entry 6qvw coloured by chain, ensemble of 30 models, front view.
PDB entry 6qvw coloured by chain, ensemble of 30 models, side view.
PDB entry 6qvw coloured by chain, ensemble of 30 models, top view.
Source organism: Homo sapiens
Primary publication:
Forkhead Domains of FOXO Transcription Factors Differ in both Overall Conformation and Dynamics.
Psenakova K, Kohoutova K, Obsilova V, Ausserlechner MJ, Veverka V, Obsil T
Cells 8 (2019)
PMID: 31450545

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171391 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Forkhead box protein O1 Chain: A
Molecule details ›
Chain: A
Length: 119 amino acids
Theoretical weight: 13.21 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q12778 (Residues: 159-272; Coverage: 17%)
Gene names: FKHR, FOXO1, FOXO1A
Sequence domains: Forkhead domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 90%
Refinement method: molecular dynamics
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

6 review citations

A Review of FoxO1-Regulated Metabolic Diseases and Related Drug Discoveries.
Peng et al. (2020)
5 more

5 mentions without citation

Toward a mechanistic understanding of DNA binding by forkhead transcription factors and its perturbation by pathogenic mutations.
Dai et al. (2021)
4 more