Function and Biology Details
Reaction catalysed:
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1)
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
- Influenza RNA-dependent RNA polymerase subunit PB1
- PB2, C-terminal
- Influenza RNA-dependent RNA polymerase subunit PB2
- RNA-directed RNA polymerase, negative-strand RNA virus
- Influenza RNA-dependent RNA polymerase subunit PA
- Influenza RNA-dependent RNA polymerase subunit PA, endonuclease domain
- Polymerase acidic protein
Structure analysis Details
Assembly composition:
hetero pentamer (preferred)
PDBe Complex ID:
PDB-CPX-128738 (preferred)
Entry contents:
3 distinct polypeptide molecules
2 distinct RNA molecules
2 distinct RNA molecules
Macromolecules (5 distinct):
Polymerase acidic protein
Molecule details ›
Chain: E
Length: 726 amino acids
Theoretical weight: 83.16 KDa
Source organism: Influenza B virus (B/Panama/45/1990)
Expression system: Spodoptera frugiperda
UniProt:
Sequence domains: Influenza RNA-dependent RNA polymerase subunit PA
Length: 726 amino acids
Theoretical weight: 83.16 KDa
Source organism: Influenza B virus (B/Panama/45/1990)
Expression system: Spodoptera frugiperda
UniProt:
- Canonical:
O36432 (Residues: 1-726; Coverage: 100%)
Sequence domains: Influenza RNA-dependent RNA polymerase subunit PA
RNA-directed RNA polymerase catalytic subunit
Molecule details ›
Chain: K
Length: 752 amino acids
Theoretical weight: 84.38 KDa
Source organism: Influenza B virus (B/Panama/45/1990)
Expression system: Spodoptera frugiperda
UniProt:
Sequence domains: Influenza RNA-dependent RNA polymerase subunit PB1
Length: 752 amino acids
Theoretical weight: 84.38 KDa
Source organism: Influenza B virus (B/Panama/45/1990)
Expression system: Spodoptera frugiperda
UniProt:
- Canonical: O36430 (Residues: 1-752; Coverage: 100%)
Sequence domains: Influenza RNA-dependent RNA polymerase subunit PB1
Polymerase basic protein 2
Molecule details ›
Chain: Q
Length: 778 amino acids
Theoretical weight: 89.1 KDa
Source organism: Influenza B virus (B/Panama/45/1990)
Expression system: Spodoptera frugiperda
UniProt:
Sequence domains:
Length: 778 amino acids
Theoretical weight: 89.1 KDa
Source organism: Influenza B virus (B/Panama/45/1990)
Expression system: Spodoptera frugiperda
UniProt:
- Canonical: O36431 (Residues: 1-770; Coverage: 100%)
Sequence domains:
- Influenza RNA polymerase PB2 N-terminal region
- Influenza RNA polymerase PB2 second domain
- Influenza RNA polymerase PB2 middle domain
- Influenza RNA polymerase PB2 helical domain
- Influenza RNA polymerase PB2 CAP binding domain
- Influenza RNA polymerase PB2 6th domain
- Influenza RNA polymerase PB2 C-terminal domain
