› 6qzp

Electron Microscopy
2.9Å resolution

High-resolution cryo-EM structure of the human 80S ribosome

Released:
DOI: 10.2210/pdb6qzp/pdb
PDB entry 6qzp coloured by chain, front view.
PDB entry 6qzp coloured by chain, side view.
PDB entry 6qzp coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Visualization of chemical modifications in the human 80S ribosome structure.
Natchiar SK, Myasnikov AG, Kratzat H, Hazemann I, Klaholz BP
Nature 551 472-477 (2017)
PMID: 29143818
Related structures: EMD-3883

Function and Biology Details

Reaction catalysed: 
The C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero 81-mer (preferred)
PDBe Complex ID:
PDB-CPX-140322 (preferred)
Entry contents:
76 distinct polypeptide molecules
5 distinct RNA molecules
Macromolecules (81 distinct):
Large ribosomal subunit protein uL2 Chain: LA
Molecule details ›
Chain: LA
Length: 248 amino acids
Theoretical weight: 27 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P62917 (Residues: 2-249; Coverage: 97%)
Gene name: RPL8
Sequence domains:
Large ribosomal subunit protein uL3 Chain: LB
Molecule details ›
Chain: LB
Length: 402 amino acids
Theoretical weight: 46.08 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P39023 (Residues: 2-403; Coverage: 100%)
Gene names: OK/SW-cl.32, RPL3
Sequence domains: Ribosomal protein L3
Large ribosomal subunit protein uL4 Chain: LC
Molecule details ›
Chain: LC
Length: 368 amino acids
Theoretical weight: 41.76 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P36578 (Residues: 1-368; Coverage: 86%)
Gene names: RPL1, RPL4
Sequence domains:
Large ribosomal subunit protein uL18 Chain: LD
Molecule details ›
Chain: LD
Length: 293 amino acids
Theoretical weight: 34.01 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P46777 (Residues: 2-294; Coverage: 99%)
Gene names: MSTP030, RPL5
Sequence domains:
Large ribosomal subunit protein eL6 Chain: LE
Molecule details ›
Chain: LE
Length: 236 amino acids
Theoretical weight: 27.03 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q02878 (Residues: 42-288; Coverage: 82%)
Gene names: RPL6, TXREB1
Sequence domains:
Large ribosomal subunit protein uL30 Chain: LF
Molecule details ›
Chain: LF
Length: 225 amino acids
Theoretical weight: 26.59 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P18124 (Residues: 24-248; Coverage: 91%)
Gene name: RPL7
Sequence domains:
Large ribosomal subunit protein eL8 Chain: LG
Molecule details ›
Chain: LG
Length: 241 amino acids
Theoretical weight: 27.45 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P62424 (Residues: 26-266; Coverage: 91%)
Gene names: RPL7A, SURF-3, SURF3
Sequence domains: Ribosomal protein L7Ae/L30e/S12e/Gadd45 family
Large ribosomal subunit protein uL6 Chain: LH
Molecule details ›
Chain: LH
Length: 190 amino acids
Theoretical weight: 21.66 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P32969 (Residues: 1-190; Coverage: 99%)
Gene names: OK/SW-cl.103, RPL9, RPL9P7, RPL9P8, RPL9P9
Sequence domains: Ribosomal protein L6
Ribosomal protein uL16-like Chain: LI
Molecule details ›
Chain: LI
Length: 213 amino acids
Theoretical weight: 24.44 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q96L21 (Residues: 2-214; Coverage: 100%)
Gene name: RPL10L
Sequence domains: Ribosomal protein L16p/L10e
Large ribosomal subunit protein uL5 Chain: LJ
Molecule details ›
Chain: LJ
Length: 176 amino acids
Theoretical weight: 20.09 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P62913 (Residues: 3-178; Coverage: 99%)
Gene name: RPL11
Sequence domains:
Large ribosomal subunit protein eL13 Chain: LL
Molecule details ›
Chain: LL
Length: 210 amino acids
Theoretical weight: 24.19 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P26373 (Residues: 2-211; Coverage: 100%)
Gene names: BBC1, OK/SW-cl.46, RPL13
Sequence domains: Ribosomal protein L13e
Large ribosomal subunit protein eL14 Chain: LM
Molecule details ›
Chain: LM
Length: 139 amino acids
Theoretical weight: 16.22 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P50914 (Residues: 2-140; Coverage: 65%)
Gene name: RPL14
Sequence domains: Ribosomal protein L14
Large ribosomal subunit protein eL15 Chain: LN
Molecule details ›
Chain: LN
Length: 203 amino acids
Theoretical weight: 24.08 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P61313 (Residues: 2-204; Coverage: 100%)
Gene names: EC45, RPL15, TCBAP0781
Sequence domains: Ribosomal L15
Large ribosomal subunit protein uL13 Chain: LO
Molecule details ›
Chain: LO
Length: 201 amino acids
Theoretical weight: 23.43 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P40429 (Residues: 3-203; Coverage: 99%)
Gene name: RPL13A
Sequence domains: Ribosomal protein L13
Large ribosomal subunit protein uL22 Chain: LP
Molecule details ›
Chain: LP
Length: 153 amino acids
Theoretical weight: 17.76 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P18621 (Residues: 2-154; Coverage: 83%)
Gene name: RPL17
Sequence domains: Ribosomal protein L22p/L17e
Large ribosomal subunit protein eL18 Chain: LQ
Molecule details ›
Chain: LQ
Length: 187 amino acids
Theoretical weight: 21.56 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q07020 (Residues: 2-188; Coverage: 100%)
Gene name: RPL18
Sequence domains: Ribosomal protein 60S L18 and 50S L18e
Large ribosomal subunit protein eL19 Chain: LR
Molecule details ›
Chain: LR
Length: 187 amino acids
Theoretical weight: 22.44 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P84098 (Residues: 2-188; Coverage: 95%)
Gene name: RPL19
Sequence domains: Ribosomal protein L19e
Large ribosomal subunit protein eL20 Chain: LS
Molecule details ›
Chain: LS
Length: 175 amino acids
Theoretical weight: 20.68 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q02543 (Residues: 2-176; Coverage: 99%)
Gene name: RPL18A
Sequence domains: Ribosomal proteins 50S-L18Ae/60S-L20/60S-L18A
Large ribosomal subunit protein eL21 Chain: LT
Molecule details ›
Chain: LT
Length: 159 amino acids
Theoretical weight: 18.48 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P46778 (Residues: 2-160; Coverage: 99%)
Gene name: RPL21
Sequence domains: Ribosomal protein L21e
Large ribosomal subunit protein eL22 Chain: LU
Molecule details ›
Chain: LU
Length: 101 amino acids
Theoretical weight: 11.72 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P35268 (Residues: 17-117; Coverage: 79%)
Gene name: RPL22
Sequence domains: Ribosomal L22e protein family
Large ribosomal subunit protein uL14 Chain: LV
Molecule details ›
Chain: LV
Length: 131 amino acids
Theoretical weight: 13.97 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P62829 (Residues: 10-140; Coverage: 94%)
Gene name: RPL23
Sequence domains: Ribosomal protein L14p/L23e
Large ribosomal subunit protein eL24 Chain: LW
Molecule details ›
Chain: LW
Length: 124 amino acids
Theoretical weight: 14.48 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P83731 (Residues: 1-124; Coverage: 79%)
Gene name: RPL24
Sequence domains: Ribosomal protein L24e
Large ribosomal subunit protein uL23 Chain: LX
Molecule details ›
Chain: LX
Length: 120 amino acids
Theoretical weight: 13.99 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P62750 (Residues: 37-156; Coverage: 77%)
Gene name: RPL23A
Sequence domains:
Large ribosomal subunit protein uL24 Chain: LY
Molecule details ›
Chain: LY
Length: 134 amino acids
Theoretical weight: 15.89 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P61254 (Residues: 1-134; Coverage: 92%)
Gene name: RPL26
Sequence domains:
Large ribosomal subunit protein eL27 Chain: LZ
Molecule details ›
Chain: LZ
Length: 135 amino acids
Theoretical weight: 15.7 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P61353 (Residues: 2-136; Coverage: 99%)
Gene name: RPL27
Sequence domains:
Large ribosomal subunit protein uL15 Chain: La
Molecule details ›
Chain: La
Length: 147 amino acids
Theoretical weight: 16.47 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P46776 (Residues: 2-148; Coverage: 99%)
Gene name: RPL27A
Sequence domains: Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A
Large ribosomal subunit protein eL29 Chain: Lb
Molecule details ›
Chain: Lb
Length: 109 amino acids
Theoretical weight: 12.6 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P47914 (Residues: 2-122; Coverage: 69%)
Gene name: RPL29
Sequence domains: Ribosomal L29e protein family
Large ribosomal subunit protein eL30 Chain: Lc
Molecule details ›
Chain: Lc
Length: 98 amino acids
Theoretical weight: 10.95 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P62888 (Residues: 9-106; Coverage: 85%)
Gene name: RPL30
Sequence domains: Ribosomal protein L7Ae/L30e/S12e/Gadd45 family
Large ribosomal subunit protein eL31 Chain: Ld
Molecule details ›
Chain: Ld
Length: 107 amino acids
Theoretical weight: 12.64 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P62899 (Residues: 18-124; Coverage: 86%)
Gene name: RPL31
Sequence domains: Ribosomal protein L31e
Large ribosomal subunit protein eL32 Chain: Le
Molecule details ›
Chain: Le
Length: 128 amino acids
Theoretical weight: 15.02 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P62910 (Residues: 2-129; Coverage: 95%)
Gene names: PP9932, RPL32
Sequence domains: Ribosomal protein L32
Large ribosomal subunit protein eL33 Chain: Lf
Molecule details ›
Chain: Lf
Length: 109 amino acids
Theoretical weight: 12.43 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P18077 (Residues: 2-110; Coverage: 99%)
Gene names: GIG33, RPL35A
Sequence domains: Ribosomal protein L35Ae
Large ribosomal subunit protein eL34 Chain: Lg
Molecule details ›
Chain: Lg
Length: 114 amino acids
Theoretical weight: 12.99 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P49207 (Residues: 2-115; Coverage: 97%)
Gene name: RPL34
Sequence domains: Ribosomal protein L34e
Large ribosomal subunit protein uL29 Chain: Lh
Molecule details ›
Chain: Lh
Length: 122 amino acids
Theoretical weight: 14.46 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P42766 (Residues: 2-123; Coverage: 99%)
Gene name: RPL35
Sequence domains: Ribosomal L29 protein
Large ribosomal subunit protein eL36 Chain: Li
Molecule details ›
Chain: Li
Length: 102 amino acids
Theoretical weight: 11.92 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9Y3U8 (Residues: 2-103; Coverage: 97%)
Gene name: RPL36
Sequence domains: Ribosomal protein L36e
Large ribosomal subunit protein eL37 Chain: Lj
Molecule details ›
Chain: Lj
Length: 86 amino acids
Theoretical weight: 10.09 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P61927 (Residues: 2-87; Coverage: 89%)
Gene name: RPL37
Sequence domains: Ribosomal protein L37e
Large ribosomal subunit protein eL38 Chain: Lk
Molecule details ›
Chain: Lk
Length: 69 amino acids
Theoretical weight: 8.11 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P63173 (Residues: 2-70; Coverage: 99%)
Gene name: RPL38
Sequence domains: Ribosomal L38e protein family
Large ribosomal subunit protein eL39 Chain: Ll
Molecule details ›
Chain: Ll
Length: 50 amino acids
Theoretical weight: 6.3 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P62891 (Residues: 2-51; Coverage: 98%)
Gene name: RPL39
Sequence domains: Ribosomal L39 protein
Large ribosomal subunit protein eL40 Chain: Lm
Molecule details ›
Chain: Lm
Length: 52 amino acids
Theoretical weight: 6.21 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P62987 (Residues: 77-128; Coverage: 41%)
Gene names: UBA52, UBCEP2
Sequence domains: Ribosomal L40e family
Small ribosomal subunit protein eS32 Chain: Ln
Molecule details ›
Chain: Ln
Length: 24 amino acids
Theoretical weight: 3.34 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P62945 (Residues: 1-24; Coverage: 96%)
Gene name: RPL41
Sequence domains: Ribosomal protein L41
Large ribosomal subunit protein eL42 Chain: Lo
Molecule details ›
Chain: Lo
Length: 105 amino acids
Theoretical weight: 12.35 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P83881 (Residues: 2-106; Coverage: 99%)
Gene names: GIG15, MIG6, RPL36A, RPL44
Sequence domains: Ribosomal protein L44
Large ribosomal subunit protein eL43 Chain: Lp
Molecule details ›
Chain: Lp
Length: 91 amino acids
Theoretical weight: 10.17 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P61513 (Residues: 2-92; Coverage: 99%)
Gene name: RPL37A
Sequence domains: Ribosomal L37ae protein family
Large ribosomal subunit protein eL28 Chain: Lr
Molecule details ›
Chain: Lr
Length: 125 amino acids
Theoretical weight: 14.32 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P46779 (Residues: 2-126; Coverage: 91%)
Gene name: RPL28
Sequence domains: Ribosomal L28e protein family
Large ribosomal subunit protein uL1 Chain: Lz
Molecule details ›
Chain: Lz
Length: 217 amino acids
Theoretical weight: 24.88 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P62906 (Residues: 1-217; Coverage: 100%)
Gene names: NEDD6, RPL10A
Sequence domains: Ribosomal protein L1p/L10e family
Small ribosomal subunit protein uS2 Chain: SA
Molecule details ›
Chain: SA
Length: 221 amino acids
Theoretical weight: 24.77 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P08865 (Residues: 3-223; Coverage: 75%)
Gene names: LAMBR, LAMR1, RPSA
Sequence domains: Ribosomal protein S2
Small ribosomal subunit protein eS1 Chain: SB
Molecule details ›
Chain: SB
Length: 214 amino acids
Theoretical weight: 24.89 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P61247 (Residues: 21-234; Coverage: 81%)
Gene names: FTE1, MFTL, RPS3A
Sequence domains: Ribosomal S3Ae family
Small ribosomal subunit protein uS3 Chain: SD
Molecule details ›
Chain: SD
Length: 227 amino acids
Theoretical weight: 25.17 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P23396 (Residues: 1-227; Coverage: 93%)
Gene names: OK/SW-cl.26, RPS3
Sequence domains:
Small ribosomal subunit protein eS4, X isoform Chain: SE
Molecule details ›
Chain: SE
Length: 262 amino acids
Theoretical weight: 29.52 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P62701 (Residues: 2-263; Coverage: 100%)
Gene names: CCG2, RPS4, RPS4X, SCAR
Sequence domains:
Small ribosomal subunit protein uS7 Chain: SF
Molecule details ›
Chain: SF
Length: 189 amino acids
Theoretical weight: 21.33 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P46782 (Residues: 16-204; Coverage: 93%)
Gene name: RPS5
Sequence domains: Ribosomal protein S7p/S5e
Small ribosomal subunit protein eS7 Chain: SH
Molecule details ›
Chain: SH
Length: 186 amino acids
Theoretical weight: 21.26 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P62081 (Residues: 5-193; Coverage: 96%)
Gene name: RPS7
Sequence domains: Ribosomal protein S7e
Small ribosomal subunit protein eS8 Chain: SI
Molecule details ›
Chain: SI
Length: 206 amino acids
Theoretical weight: 24 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P62241 (Residues: 2-207; Coverage: 99%)
Gene names: OK/SW-cl.83, RPS8
Sequence domains: Ribosomal protein S8e
Small ribosomal subunit protein eS10 Chain: SK
Molecule details ›
Chain: SK
Length: 98 amino acids
Theoretical weight: 11.77 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P46783 (Residues: 1-98; Coverage: 59%)
Gene name: RPS10
Sequence domains: Plectin/S10 domain
Small ribosomal subunit protein uS17 Chain: SL
Molecule details ›
Chain: SL
Length: 153 amino acids
Theoretical weight: 17.79 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P62280 (Residues: 2-154; Coverage: 97%)
Gene name: RPS11
Sequence domains:
Small ribosomal subunit protein uS19 Chain: SP
Molecule details ›
Chain: SP
Length: 127 amino acids
Theoretical weight: 14.93 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P62841 (Residues: 10-136; Coverage: 88%)
Gene names: RIG, RPS15
Sequence domains: Ribosomal protein S19
Small ribosomal subunit protein uS9 Chain: SQ
Molecule details ›
Chain: SQ
Length: 141 amino acids
Theoretical weight: 15.98 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P62249 (Residues: 6-146; Coverage: 97%)
Gene name: RPS16
Sequence domains: Ribosomal protein S9/S16
Small ribosomal subunit protein eS17 Chain: SR
Molecule details ›
Chain: SR
Length: 135 amino acids
Theoretical weight: 15.58 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P08708 (Residues: 1-135; Coverage: 100%)
Gene names: RPS17, RPS17L
Sequence domains: Ribosomal S17
Small ribosomal subunit protein uS13 Chain: SS
Molecule details ›
Chain: SS
Length: 145 amino acids
Theoretical weight: 17.03 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P62269 (Residues: 1-145; Coverage: 95%)
Gene names: D6S218E, RPS18
Sequence domains: Ribosomal protein S13/S18
Small ribosomal subunit protein eS19 Chain: ST
Molecule details ›
Chain: ST
Length: 143 amino acids
Theoretical weight: 15.82 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P39019 (Residues: 2-144; Coverage: 99%)
Gene name: RPS19
Sequence domains: Ribosomal protein S19e
Small ribosomal subunit protein uS10 Chain: SU
Molecule details ›
Chain: SU
Length: 103 amino acids
Theoretical weight: 11.69 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P60866 (Residues: 17-119; Coverage: 87%)
Gene name: RPS20
Sequence domains: Ribosomal protein S10p/S20e
Small ribosomal subunit protein eS21 Chain: SV
Molecule details ›
Chain: SV
Length: 83 amino acids
Theoretical weight: 9.12 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P63220 (Residues: 1-83; Coverage: 100%)
Gene name: RPS21
Sequence domains: Ribosomal protein S21e
Small ribosomal subunit protein uS12 Chain: SX
Molecule details ›
Chain: SX
Length: 141 amino acids
Theoretical weight: 15.63 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P62266 (Residues: 2-142; Coverage: 99%)
Gene name: RPS23
Sequence domains: Ribosomal protein S12/S23
Small ribosomal subunit protein eS26 Chain: Sa
Molecule details ›
Chain: Sa
Length: 102 amino acids
Theoretical weight: 11.74 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P62854 (Residues: 2-103; Coverage: 89%)
Gene name: RPS26
Sequence domains: Ribosomal protein S26e
Small ribosomal subunit protein eS28 Chain: Sc
Molecule details ›
Chain: Sc
Length: 64 amino acids
Theoretical weight: 7.26 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P62857 (Residues: 5-68; Coverage: 93%)
Gene name: RPS28
Sequence domains: Ribosomal protein S28e
Small ribosomal subunit protein uS14 Chain: Sd
Molecule details ›
Chain: Sd
Length: 55 amino acids
Theoretical weight: 6.56 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P62273 (Residues: 2-56; Coverage: 98%)
Gene name: RPS29
Sequence domains: Ribosomal protein S14p/S29e
Small ribosomal subunit protein RACK1 Chain: Sg
Molecule details ›
Chain: Sg
Length: 313 amino acids
Theoretical weight: 34.67 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P63244 (Residues: 2-314; Coverage: 99%)
Gene names: GNB2L1, HLC7, PIG21, RACK1
Sequence domains: WD domain, G-beta repeat
Small ribosomal subunit protein uS5 Chain: SC
Molecule details ›
Chain: SC
Length: 222 amino acids
Theoretical weight: 24.59 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P15880 (Residues: 59-280; Coverage: 76%)
Gene names: RPS2, RPS4
Sequence domains:
Small ribosomal subunit protein eS6 Chain: SG
Molecule details ›
Chain: SG
Length: 237 amino acids
Theoretical weight: 27.47 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P62753 (Residues: 1-237; Coverage: 95%)
Gene names: OK/SW-cl.2, RPS6
Sequence domains: Ribosomal protein S6e
Small ribosomal subunit protein uS4 Chain: SJ
Molecule details ›
Chain: SJ
Length: 185 amino acids
Theoretical weight: 21.65 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P46781 (Residues: 2-186; Coverage: 95%)
Gene name: RPS9
Sequence domains:
Small ribosomal subunit protein eS12 Chain: SM
Molecule details ›
Chain: SM
Length: 122 amino acids
Theoretical weight: 13.65 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P25398 (Residues: 11-132; Coverage: 92%)
Gene name: RPS12
Sequence domains: Ribosomal protein L7Ae/L30e/S12e/Gadd45 family
Small ribosomal subunit protein uS15 Chain: SN
Molecule details ›
Chain: SN
Length: 150 amino acids
Theoretical weight: 17.13 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P62277 (Residues: 2-151; Coverage: 99%)
Gene name: RPS13
Sequence domains:
Small ribosomal subunit protein uS11 Chain: SO
Molecule details ›
Chain: SO
Length: 140 amino acids
Theoretical weight: 15.01 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P62263 (Residues: 12-151; Coverage: 93%)
Gene names: PRO2640, RPS14
Sequence domains: Ribosomal protein S11
Small ribosomal subunit protein uS8 Chain: SW
Molecule details ›
Chain: SW
Length: 129 amino acids
Theoretical weight: 14.73 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P62244 (Residues: 2-130; Coverage: 99%)
Gene names: OK/SW-cl.82, RPS15A
Sequence domains: Ribosomal protein S8
Small ribosomal subunit protein eS24 Chain: SY
Molecule details ›
Chain: SY
Length: 131 amino acids
Theoretical weight: 15.2 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P62847 (Residues: 2-132; Coverage: 99%)
Gene name: RPS24
Sequence domains: Ribosomal protein S24e
Small ribosomal subunit protein eS25 Chain: SZ
Molecule details ›
Chain: SZ
Length: 75 amino acids
Theoretical weight: 8.53 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P62851 (Residues: 41-115; Coverage: 60%)
Gene name: RPS25
Sequence domains: S25 ribosomal protein
Small ribosomal subunit protein eS27 Chain: Sb
Molecule details ›
Chain: Sb
Length: 83 amino acids
Theoretical weight: 9.35 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P42677 (Residues: 2-84; Coverage: 99%)
Gene names: MPS1, RPS27
Sequence domains: Ribosomal protein S27
Small ribosomal subunit protein eS30 Chain: Se
Molecule details ›
Chain: Se
Length: 58 amino acids
Theoretical weight: 6.54 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P62861 (Residues: 76-133; Coverage: 44%)
Gene name: FAU
Sequence domains: Ribosomal protein S30
Small ribosomal subunit protein eS31 Chain: Sf
Molecule details ›
Chain: Sf
Length: 67 amino acids
Theoretical weight: 7.88 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P62979 (Residues: 85-151; Coverage: 43%)
Gene names: RPS27A, UBA80, UBCEP1
Sequence domains: Ribosomal protein S27a
28S rRNA (3773-MER) Chain: L5
Molecule details ›
Chain: L5
Length: 3773 nucleotides
Theoretical weight: 1223.36 KDa
Sequence domains: Eukaryotic large subunit ribosomal RNA
5S rRNA (120-MER) Chain: L7
Molecule details ›
Chain: L7
Length: 120 nucleotides
Theoretical weight: 38.69 KDa
Sequence domains: 5S ribosomal RNA
5.8S rRNA (156-MER) Chain: L8
Molecule details ›
Chain: L8
Length: 156 nucleotides
Theoretical weight: 50.16 KDa
Sequence domains: 5.8S ribosomal RNA
18S rRNA (1740-MER) Chain: S2
Molecule details ›
Chain: S2
Length: 1740 nucleotides
Theoretical weight: 561.9 KDa
Sequence domains: Eukaryotic small subunit ribosomal RNA
E site tRNA (75-MER) Chain: S6
Molecule details ›
Chain: S6
Length: 75 nucleotides
Theoretical weight: 24.23 KDa
Sequence domains: tRNA

Ligands and Environments

4 bound ligands:
Ligand MG 438 x MG
Ligand HMT 1 x HMT
Ligand ZN 8 x ZN
Ligand HYG 1 x HYG
17 modified residues:
Ligand OMG 20 x OMG
Ligand A2M 21 x A2M
Ligand 2MG 4 x 2MG
Ligand 1MA 2 x 1MA
Ligand JMH 2 x JMH
Ligand PSU 21 x PSU
Ligand B8H 3 x B8H
Ligand UR3 4 x UR3
Ligand OMC 13 x OMC
Ligand 5MC 4 x 5MC
Ligand 5MU 2 x 5MU
Ligand 6MZ 2 x 6MZ
Ligand OMU 5 x OMU
Ligand B8T 2 x B8T
Ligand MLZ 2 x MLZ
Ligand M7A 1 x M7A
Ligand MA6 2 x MA6

Experiments and Validation Details

Entry percentile scores
Resolution: 2.9Å
Relevant EMDB volumes: EMD-3883

Quick links

Citations

53 review citations

The role of m6A, m5C and Ψ RNA modifications in cancer: Novel therapeutic opportunities.
Nombela et al. (2021)
52 more

17 mentions without citation

Specialized Ribosomes in Health and Disease.
Miller et al. (2023)
16 more