› 6qzw

X-ray diffraction
3.2Å resolution

Function and Biology Details

Reaction catalysed: 
Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-167353 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Dipeptidyl peptidase 8 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 898 amino acids
Theoretical weight: 103.48 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q6V1X1 (Residues: 1-898; Coverage: 100%)
Gene names: DPP8, DPRP1, MSTP097, MSTP135, MSTP141
Sequence domains:
MET-PRO Chains: D, E, F
Molecule details ›
Chains: D, E, F
Length: 2 amino acids
Theoretical weight: 246 Da
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

1 bound ligand:
Ligand NA 1 x NA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: C2221
Unit cell:
a: 162.73Å b: 246.074Å c: 261.812Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.186 0.184 0.225
Expression systems:
  • Spodoptera frugiperda
  • Not provided

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