› 6r7d

X-ray diffraction
2.35Å resolution

Function and Biology Details

Reaction catalysed: 
Leukotriene C(4) = leukotriene A(4) + glutathione
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-172606 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Leukotriene C4 synthase Chains: A, B, C, D, E, F, G, H, I, J, K, L
Molecule details ›
Chains: A, B, C, D, E, F, G, H, I, J, K, L
Length: 157 amino acids
Theoretical weight: 17.48 KDa
Source organism: Homo sapiens
Expression system: Komagataella pastoris
UniProt:
  • Canonical: Q16873 (Residues: 2-150; Coverage: 99%)
Gene name: LTC4S
Sequence domains: MAPEG family

Ligands and Environments

4 bound ligands:
Ligand JUQ 12 x JUQ
Ligand NI 8 x NI
Ligand PLM 43 x PLM
Ligand LMT 1 x LMT
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-1
Spacegroup: P212121
Unit cell:
a: 121.591Å b: 169.385Å c: 174.478Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.209 0.208 0.23
Expression system: Komagataella pastoris

Quick links

Citations

2 review citations

Untangling the web of 5-lipoxygenase-derived products from a molecular and structural perspective: The battle between pro- and anti-inflammatory lipid mediators.
Gilbert et al. (2021)
1 more