› 6r7q

Electron Microscopy
3.9Å resolution

Structure of XBP1u-paused ribosome nascent chain complex with Sec61.

Released:
DOI: 10.2210/pdb6r7q/pdb
PDB entry 6r7q coloured by chain, front view.
PDB entry 6r7q coloured by chain, side view.
PDB entry 6r7q coloured by chain, top view.
Source organisms:
Primary publication:
Structural and mutational analysis of the ribosome-arresting human XBP1u.
Shanmuganathan V, Schiller N, Magoulopoulou A, Cheng J, Braunger K, Cymer F, Berninghausen O, Beatrix B, Kohno K, von Heijne G, Beckmann R
Elife 8 (2019)
PMID: 31246176
Related structures: EMD-4745

Function and Biology Details

Reaction catalysed: 
The C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero 88-mer (preferred)
PDBe Complex ID:
PDB-CPX-243257 (preferred)
Entry contents:
81 distinct polypeptide molecules
7 distinct RNA molecules
Macromolecules (88 distinct):
Small ribosomal subunit protein eS30 Chain: AA
Molecule details ›
Chain: AA
Length: 55 amino acids
Theoretical weight: 6.32 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1T8A2 (Residues: 79-133; Coverage: 41%)
Gene name: FAU
Sequence domains: Ribosomal protein S30
Small ribosomal subunit protein eS7 Chain: BB
Molecule details ›
Chain: BB
Length: 189 amino acids
Theoretical weight: 21.63 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1SVB0 (Residues: 244-432; Coverage: 44%)
Gene name: RPS7
Sequence domains: Ribosomal protein S7e
Small ribosomal subunit protein eS8 Chain: CC
Molecule details ›
Chain: CC
Length: 206 amino acids
Theoretical weight: 24 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1TJW1 (Residues: 2-207; Coverage: 99%)
Gene name: RPS8
Sequence domains: Ribosomal protein S8e
Small ribosomal subunit protein uS4 Chain: DD
Molecule details ›
Chain: DD
Length: 185 amino acids
Theoretical weight: 21.65 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: B7NZS8 (Residues: 2-186; Coverage: 95%)
Gene name: RPS9
Sequence domains:
Small ribosomal subunit protein uS17 Chain: EE
Molecule details ›
Chain: EE
Length: 151 amino acids
Theoretical weight: 17.59 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1TRM4 (Residues: 3-153; Coverage: 96%)
Gene name: RPS11
Sequence domains:
Small ribosomal subunit protein eS28 Chain: FF
Molecule details ›
Chain: FF
Length: 62 amino acids
Theoretical weight: 7.01 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1TIB4 (Residues: 7-68; Coverage: 90%)
Gene name: RPS28
Sequence domains: Ribosomal protein S28e
uS10 Chain: GG
Molecule details ›
Chain: GG
Length: 100 amino acids
Theoretical weight: 11.4 KDa
Source organism: Oryctolagus cuniculus
eS21 Chain: HH
Molecule details ›
Chain: HH
Length: 83 amino acids
Theoretical weight: 9.12 KDa
Source organism: Oryctolagus cuniculus
Small ribosomal subunit protein uS13 Chain: II
Molecule details ›
Chain: II
Length: 144 amino acids
Theoretical weight: 16.9 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1TPG3 (Residues: 2-145; Coverage: 95%)
Gene name: RPS18
Sequence domains: Ribosomal protein S13/S18
Small ribosomal subunit protein eS27 Chain: JJ
Molecule details ›
Chain: JJ
Length: 83 amino acids
Theoretical weight: 9.35 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1TZ76 (Residues: 2-84; Coverage: 99%)
Gene name: RPS27
Sequence domains: Ribosomal protein S27
Small ribosomal subunit protein eS17 Chain: KK
Molecule details ›
Chain: KK
Length: 132 amino acids
Theoretical weight: 15.25 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1TU13 (Residues: 2-133; Coverage: 98%)
Gene name: RPS17
Sequence domains: Ribosomal S17
eS26 Chain: LL
Molecule details ›
Chain: LL
Length: 101 amino acids
Theoretical weight: 11.65 KDa
Source organism: Oryctolagus cuniculus
uS11 Chain: MM
Molecule details ›
Chain: MM
Length: 136 amino acids
Theoretical weight: 14.54 KDa
Source organism: Oryctolagus cuniculus
Small ribosomal subunit protein eS31 Chain: 0
Molecule details ›
Chain: 0
Length: 68 amino acids
Theoretical weight: 7.99 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1SK22 (Residues: 115-182; Coverage: 36%)
Gene name: RPS27A
Sequence domains: Ribosomal protein S27a
X-box-binding protein 1, luminal form Chain: 1
Molecule details ›
Chain: 1
Length: 24 amino acids
Theoretical weight: 2.9 KDa
Source organism: Homo sapiens
Expression system: Oryctolagus cuniculus
UniProt:
  • Canonical: P17861 (Residues: 237-260; Coverage: 9%)
Gene names: TREB5, XBP1, XBP2
Small ribosomal subunit protein RACK1 Chain: 6
Molecule details ›
Chain: 6
Length: 313 amino acids
Theoretical weight: 34.67 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1SJB4 (Residues: 117-421; Coverage: 72%)
Gene name: RACK1
Sequence domains: WD domain, G-beta repeat
Small ribosomal subunit protein uS14 Chain: 9
Molecule details ›
Chain: 9
Length: 55 amino acids
Theoretical weight: 6.56 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1U7M4 (Residues: 2-56; Coverage: 98%)
Gene name: RPS29
Sequence domains: Ribosomal protein S14p/S29e
eS24 Chain: NN
Molecule details ›
Chain: NN
Length: 124 amino acids
Theoretical weight: 14.43 KDa
Source organism: Oryctolagus cuniculus
Small ribosomal subunit protein eS25 Chain: OO
Molecule details ›
Chain: OO
Length: 75 amino acids
Theoretical weight: 8.53 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1TDB3 (Residues: 40-114; Coverage: 61%)
Gene name: RPS25
Sequence domains: S25 ribosomal protein
Small ribosomal subunit protein eS19 Chain: PP
Molecule details ›
Chain: PP
Length: 141 amino acids
Theoretical weight: 15.61 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1TN62 (Residues: 3-143; Coverage: 97%)
Gene name: RPS19
Sequence domains: Ribosomal protein S19e
Small ribosomal subunit protein uS15 Chain: QQ
Molecule details ›
Chain: QQ
Length: 149 amino acids
Theoretical weight: 17.06 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1SP51 (Residues: 11-151; Coverage: 91%)
Gene name: RPS13
Sequence domains:
Small ribosomal subunit protein eS12 Chain: RR
Molecule details ›
Chain: RR
Length: 117 amino acids
Theoretical weight: 13.05 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1SFR8 (Residues: 14-130; Coverage: 89%)
Gene name: RPS12
Sequence domains: Ribosomal protein L7Ae/L30e/S12e/Gadd45 family
Large ribosomal subunit protein uL2 Chain: A
Molecule details ›
Chain: A
Length: 248 amino acids
Theoretical weight: 27 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1TT27 (Residues: 2-217; Coverage: 85%)
Gene name: RPL8
Sequence domains:
Large ribosomal subunit protein uL3 Chain: B
Molecule details ›
Chain: B
Length: 394 amino acids
Theoretical weight: 45.12 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1TL06 (Residues: 2-395; Coverage: 98%)
Gene name: RPL3
Sequence domains: Ribosomal protein L3
Large ribosomal subunit protein uL4 Chain: C
Molecule details ›
Chain: C
Length: 362 amino acids
Theoretical weight: 41.1 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1SVW5 (Residues: 2-363; Coverage: 88%)
Gene name: RPL4
Sequence domains:
Large ribosomal subunit protein uL18 C-terminal eukaryotes domain-containing protein Chain: D
Molecule details ›
Chain: D
Length: 293 amino acids
Theoretical weight: 34.08 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1SYJ6 (Residues: 3-295; Coverage: 99%)
Sequence domains:
Large ribosomal subunit protein eL6 Chain: E
Molecule details ›
Chain: E
Length: 251 amino acids
Theoretical weight: 28.82 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1SKF7 (Residues: 41-291; Coverage: 86%)
Gene name: RPL6
Sequence domains:
Large ribosomal subunit protein uL30 Chain: F
Molecule details ›
Chain: F
Length: 225 amino acids
Theoretical weight: 26.66 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1SV32 (Residues: 25-249; Coverage: 90%)
Gene name: RPL7
Sequence domains:
Large ribosomal subunit protein eL8 Chain: G
Molecule details ›
Chain: G
Length: 240 amino acids
Theoretical weight: 27.35 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1STW0 (Residues: 80-319; Coverage: 75%)
Gene name: RPL7A
Sequence domains: Ribosomal protein L7Ae/L30e/S12e/Gadd45 family
Large ribosomal subunit protein uL6 Chain: H
Molecule details ›
Chain: H
Length: 190 amino acids
Theoretical weight: 21.63 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1SWI6 (Residues: 1-190; Coverage: 99%)
Gene name: RPL9
Sequence domains: Ribosomal protein L6
Large ribosomal subunit protein uL16 Chain: I
Molecule details ›
Chain: I
Length: 213 amino acids
Theoretical weight: 24.51 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: B7NZQ2 (Residues: 2-214; Coverage: 100%)
Gene name: RPL10
Sequence domains: Ribosomal protein L16p/L10e
Large ribosomal subunit protein uL5 Chain: J
Molecule details ›
Chain: J
Length: 170 amino acids
Theoretical weight: 19.4 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1TUB8 (Residues: 8-177; Coverage: 96%)
Gene name: RPL11
Sequence domains:
60S ribosomal protein L13 Chain: L
Molecule details ›
Chain: L
Length: 210 amino acids
Theoretical weight: 24.2 KDa
Source organism: Oryctolagus cuniculus
Ribosomal protein L14 Chain: M
Molecule details ›
Chain: M
Length: 138 amino acids
Theoretical weight: 16.22 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: U3KNW6 (Residues: 2-139; Coverage: 63%)
Sequence domains: Ribosomal protein L14
Large ribosomal subunit protein eL15 Chain: N
Molecule details ›
Chain: N
Length: 203 amino acids
Theoretical weight: 24.08 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1T0C1 (Residues: 2-204; Coverage: 100%)
Gene name: RPL15
Sequence domains: Ribosomal L15
uL13 Chain: O
Molecule details ›
Chain: O
Length: 199 amino acids
Theoretical weight: 23.14 KDa
Source organism: Oryctolagus cuniculus
Large ribosomal subunit protein uL22 Chain: P
Molecule details ›
Chain: P
Length: 153 amino acids
Theoretical weight: 17.76 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1SCJ6 (Residues: 5-157; Coverage: 82%)
Gene name: RPL17
Sequence domains: Ribosomal protein L22p/L17e
Large ribosomal subunit protein uL15/eL18 domain-containing protein Chain: Q
Molecule details ›
Chain: Q
Length: 187 amino acids
Theoretical weight: 21.57 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1TX70 (Residues: 8-194; Coverage: 96%)
Sequence domains: Ribosomal protein 60S L18 and 50S L18e
eL19 Chain: R
Molecule details ›
Chain: R
Length: 180 amino acids
Theoretical weight: 21.61 KDa
Source organism: Oryctolagus cuniculus
eL20 Chain: S
Molecule details ›
Chain: S
Length: 176 amino acids
Theoretical weight: 20.83 KDa
Source organism: Oryctolagus cuniculus
Large ribosomal subunit protein eL21 Chain: T
Molecule details ›
Chain: T
Length: 159 amino acids
Theoretical weight: 18.48 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1SHQ2 (Residues: 2-160; Coverage: 99%)
Gene name: RPL21
Sequence domains: Ribosomal protein L21e
eL22 Chain: U
Molecule details ›
Chain: U
Length: 99 amino acids
Theoretical weight: 11.5 KDa
Source organism: Oryctolagus cuniculus
Large ribosomal subunit protein uL14 Chain: V
Molecule details ›
Chain: V
Length: 131 amino acids
Theoretical weight: 13.97 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1T6D1 (Residues: 10-140; Coverage: 94%)
Gene name: RPL23
Sequence domains: Ribosomal protein L14p/L23e
Large ribosomal subunit protein eL24 Chain: W
Molecule details ›
Chain: W
Length: 121 amino acids
Theoretical weight: 14.13 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1SE28 (Residues: 1-121; Coverage: 77%)
Gene name: RPL24
Sequence domains: Ribosomal protein L24e
Large ribosomal subunit protein uL23 Chain: X
Molecule details ›
Chain: X
Length: 118 amino acids
Theoretical weight: 13.73 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1SE76 (Residues: 39-156; Coverage: 76%)
Gene name: RPL23A
Sequence domains:
Large ribosomal subunit protein uL24 Chain: Y
Molecule details ›
Chain: Y
Length: 134 amino acids
Theoretical weight: 15.89 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1SQH0 (Residues: 1-134; Coverage: 92%)
Gene name: RPL26
Sequence domains:
Large ribosomal subunit protein eL27 Chain: Z
Molecule details ›
Chain: Z
Length: 135 amino acids
Theoretical weight: 15.7 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1TXF6 (Residues: 2-136; Coverage: 99%)
Gene name: RPL27
Sequence domains:
Small ribosomal subunit protein eS10 Chain: SS
Molecule details ›
Chain: SS
Length: 96 amino acids
Theoretical weight: 11.53 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1TPV3 (Residues: 1-96; Coverage: 58%)
Sequence domains: Plectin/S10 domain
Large ribosomal subunit protein uL15 Chain: a
Molecule details ›
Chain: a
Length: 147 amino acids
Theoretical weight: 16.49 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1SNY0 (Residues: 2-148; Coverage: 99%)
Gene name: RPL27A
Sequence domains: Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A
Large ribosomal subunit protein eL29 Chain: b
Molecule details ›
Chain: b
Length: 116 amino acids
Theoretical weight: 13.4 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1SGR6 (Residues: 2-117; Coverage: 47%)
Gene name: RPL29
Sequence domains: Ribosomal L29e protein family
Large ribosomal subunit protein eL30 Chain: c
Molecule details ›
Chain: c
Length: 98 amino acids
Theoretical weight: 10.91 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1TDL2 (Residues: 10-107; Coverage: 85%)
Gene name: RPL30
Sequence domains: Ribosomal protein L7Ae/L30e/S12e/Gadd45 family
Large ribosomal subunit protein eL31 Chain: d
Molecule details ›
Chain: d
Length: 107 amino acids
Theoretical weight: 12.64 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1SHG0 (Residues: 18-124; Coverage: 86%)
Gene name: RPL31
Sequence domains: Ribosomal protein L31e
Large ribosomal subunit protein eL32 Chain: e
Molecule details ›
Chain: e
Length: 128 amino acids
Theoretical weight: 15.02 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1TUN8 (Residues: 24-151; Coverage: 82%)
Gene name: RPL32
Sequence domains: Ribosomal protein L32
Large ribosomal subunit protein eL33 Chain: f
Molecule details ›
Chain: f
Length: 109 amino acids
Theoretical weight: 12.45 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1SF08 (Residues: 2-110; Coverage: 99%)
Gene name: RPL35A
Sequence domains: Ribosomal protein L35Ae
eL34 Chain: g
Molecule details ›
Chain: g
Length: 114 amino acids
Theoretical weight: 12.99 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1U945 (Residues: 14-127; Coverage: 88%)
Sequence domains: Ribosomal protein L34e
Large ribosomal subunit protein uL29 Chain: h
Molecule details ›
Chain: h
Length: 122 amino acids
Theoretical weight: 14.44 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1SIT5 (Residues: 2-123; Coverage: 99%)
Gene name: RPL35
Sequence domains: Ribosomal L29 protein
Large ribosomal subunit protein eL36 Chain: i
Molecule details ›
Chain: i
Length: 102 amino acids
Theoretical weight: 11.89 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1TTQ5 (Residues: 26-97; Coverage: 73%)
Gene name: RPL36
Sequence domains: Ribosomal protein L36e
Large ribosomal subunit protein eL37 Chain: j
Molecule details ›
Chain: j
Length: 86 amino acids
Theoretical weight: 10.09 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: U3KPD5 (Residues: 2-87; Coverage: 89%)
Gene name: RPL37
Sequence domains: Ribosomal protein L37e
eL38 Chain: k
Molecule details ›
Chain: k
Length: 69 amino acids
Theoretical weight: 8.11 KDa
Source organism: Oryctolagus cuniculus
Large ribosomal subunit protein eL39 Chain: l
Molecule details ›
Chain: l
Length: 50 amino acids
Theoretical weight: 6.32 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1TTN1 (Residues: 2-51; Coverage: 98%)
Sequence domains: Ribosomal L39 protein
eL40 Chain: m
Molecule details ›
Chain: m
Length: 52 amino acids
Theoretical weight: 6.2 KDa
Source organism: Oryctolagus cuniculus
Small ribosomal subunit protein eS32 Chain: n
Molecule details ›
Chain: n
Length: 25 amino acids
Theoretical weight: 3.47 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: A0A087WNH4 (Residues: 1-25; Coverage: 100%)
Gene name: RPL41
Sequence domains: Ribosomal protein L41
Large ribosomal subunit protein eL42 Chain: o
Molecule details ›
Chain: o
Length: 104 amino acids
Theoretical weight: 12.2 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1T040 (Residues: 2-100; Coverage: 89%)
Gene name: RPL36A
Sequence domains: Ribosomal protein L44
Large ribosomal subunit protein eL43 Chain: p
Molecule details ›
Chain: p
Length: 91 amino acids
Theoretical weight: 10.17 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1SY53 (Residues: 2-92; Coverage: 99%)
Gene name: RPL37A
Sequence domains: Ribosomal L37ae protein family
uS2 Chain: q
Molecule details ›
Chain: q
Length: 217 amino acids
Theoretical weight: 24.36 KDa
Source organism: Oryctolagus cuniculus
Large ribosomal subunit protein eL28 Chain: r
Molecule details ›
Chain: r
Length: 124 amino acids
Theoretical weight: 14.22 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1U7L1 (Residues: 2-125; Coverage: 91%)
Gene name: RPL28
Sequence domains: Ribosomal L28e protein family
60S acidic ribosomal protein P0 Chain: s
Molecule details ›
Chain: s
Length: 196 amino acids
Theoretical weight: 21.52 KDa
Source organism: Oryctolagus cuniculus
Large ribosomal subunit protein uL11 Chain: t
Molecule details ›
Chain: t
Length: 153 amino acids
Theoretical weight: 16.56 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1SMR7 (Residues: 9-161; Coverage: 93%)
Gene name: RPL12
Sequence domains:
Small ribosomal subunit protein eS1 Chain: u
Molecule details ›
Chain: u
Length: 213 amino acids
Theoretical weight: 24.76 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1SS70 (Residues: 21-233; Coverage: 81%)
Gene name: RPS3A
Sequence domains: Ribosomal S3Ae family
uS5 Chain: v
Molecule details ›
Chain: v
Length: 221 amino acids
Theoretical weight: 24.44 KDa
Source organism: Oryctolagus cuniculus
Small ribosomal subunit protein uS3 Chain: w
Molecule details ›
Chain: w
Length: 228 amino acids
Theoretical weight: 25.22 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1TNM3 (Residues: 39-266; Coverage: 81%)
Gene name: RPS3
Sequence domains:
Small ribosomal subunit protein eS4 Chain: x
Molecule details ›
Chain: x
Length: 262 amino acids
Theoretical weight: 29.52 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1TK17 (Residues: 2-263; Coverage: 100%)
Gene name: RPS4X
Sequence domains:
Small ribosomal subunit protein uS7 Chain: y
Molecule details ›
Chain: y
Length: 191 amino acids
Theoretical weight: 21.53 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1TFM5 (Residues: 14-204; Coverage: 94%)
Gene name: RPS5
Sequence domains: Ribosomal protein S7p/S5e
Small ribosomal subunit protein eS6 Chain: z
Molecule details ›
Chain: z
Length: 237 amino acids
Theoretical weight: 27.47 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1TM55 (Residues: 11-211; Coverage: 81%)
Gene name: RPS6
Sequence domains: Ribosomal protein S6e
Small ribosomal subunit protein uS8 Chain: TT
Molecule details ›
Chain: TT
Length: 129 amino acids
Theoretical weight: 14.73 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1TG89 (Residues: 2-130; Coverage: 99%)
Gene name: RPS15A
Sequence domains: Ribosomal protein S8
Small ribosomal subunit protein uS9 Chain: UU
Molecule details ›
Chain: UU
Length: 142 amino acids
Theoretical weight: 16.03 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1SGX4 (Residues: 31-172; Coverage: 83%)
Gene name: RPS16
Sequence domains: Ribosomal protein S9/S16
Small ribosomal subunit protein uS12 Chain: VV
Molecule details ›
Chain: VV
Length: 141 amino acids
Theoretical weight: 15.63 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1SZ47 (Residues: 2-142; Coverage: 99%)
Gene name: RPS23
Sequence domains: Ribosomal protein S12/S23
Small ribosomal subunit protein uS19 Chain: WW
Molecule details ›
Chain: WW
Length: 120 amino acids
Theoretical weight: 14.25 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1U0Q2 (Residues: 12-131; Coverage: 83%)
Gene name: RPS15
Sequence domains: Ribosomal protein S19
Protein transport protein Sec61 subunit alpha isoform 1 Chain: XX
Molecule details ›
Chain: XX
Length: 461 amino acids
Theoretical weight: 50.73 KDa
Source organism: Canis lupus familiaris
UniProt:
  • Canonical: P38377 (Residues: 5-465; Coverage: 97%)
Gene name: SEC61A1
Sequence domains:
Protein transport protein Sec61 subunit gamma Chain: YY
Molecule details ›
Chain: YY
Length: 62 amino acids
Theoretical weight: 7.02 KDa
Source organism: Canis lupus familiaris
UniProt:
  • Canonical: P60058 (Residues: 7-68; Coverage: 91%)
Gene name: SEC61G
Sequence domains: SecE/Sec61-gamma subunits of protein translocation complex
Protein transport protein Sec61 subunit beta Chain: ZZ
Molecule details ›
Chain: ZZ
Length: 29 amino acids
Theoretical weight: 3.27 KDa
Source organism: Canis lupus familiaris
UniProt:
  • Canonical: P60467 (Residues: 68-96; Coverage: 30%)
Gene name: SEC61B
Sequence domains: Sec61beta family
P-tRNA Chain: 2
Molecule details ›
Chain: 2
Length: 75 nucleotides
Theoretical weight: 24.11 KDa
Sequence domains: tRNA
E-tRNA Chain: 3
Molecule details ›
Chain: 3
Length: 75 nucleotides
Theoretical weight: 24.15 KDa
Sequence domains: tRNA
Messenger RNA Chain: 4
Molecule details ›
Chain: 4
Length: 6 nucleotides
Theoretical weight: 1.88 KDa
28S ribosomal RNA Chain: 5
Molecule details ›
Chain: 5
Length: 3544 nucleotides
Theoretical weight: 1148.46 KDa
Sequence domains: Eukaryotic large subunit ribosomal RNA
5S ribosomal RNA Chain: 7
Molecule details ›
Chain: 7
Length: 120 nucleotides
Theoretical weight: 38.69 KDa
Sequence domains: 5S ribosomal RNA
5.8S ribosomal RNA Chain: 8
Molecule details ›
Chain: 8
Length: 151 nucleotides
Theoretical weight: 48.55 KDa
Sequence domains: 5.8S ribosomal RNA
18S Ribosomal RNA Chain: K
Molecule details ›
Chain: K
Length: 1698 nucleotides
Theoretical weight: 548.04 KDa
Sequence domains: Eukaryotic small subunit ribosomal RNA

Ligands and Environments

2 bound ligands:
Ligand ZN 6 x ZN
Ligand MG 299 x MG
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.9Å
Relevant EMDB volumes: EMD-4745
Expression system: Oryctolagus cuniculus

Quick links

Citations

4 review citations

Mechanisms, regulation and functions of the unfolded protein response.
Hetz et al. (2020)
3 more

3 mentions without citation

Cancer associated mutations in Sec61γ alter the permeability of the ER translocase.
Witham et al. (2021)
2 more