› 6rbf

X-ray diffraction
2.7Å resolution

Mucin 2 D3 domain

Released:
DOI: 10.2210/pdb6rbf/pdb
PDB entry 6rbf coloured by chain, front view.
PDB entry 6rbf coloured by chain, side view.
PDB entry 6rbf coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Intestinal Gel-Forming Mucins Polymerize by Disulfide-Mediated Dimerization of D3 Domains.
Javitt G, Calvo MLG, Albert L, Reznik N, Ilani T, Diskin R, Fass D
J Mol Biol 431 3740-3752 (2019)
PMID: 31310764

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-169765 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Mucin-2 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 410 amino acids
Theoretical weight: 45.9 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q02817 (Residues: 858-1259; Coverage: 8%)
Gene names: MUC2, SMUC
Sequence domains:

Ligands and Environments

4 bound ligands:
Ligand GOL 3 x GOL
Ligand NAG 3 x NAG
Ligand CA 4 x CA
Ligand SO4 6 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06DA
Spacegroup: P21212
Unit cell:
a: 152.461Å b: 156.925Å c: 93.584Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.22 0.217 0.283
Expression system: Homo sapiens

Quick links

Citations

8 review citations

Mucins and the Microbiome.
Hansson GC. (2020)
7 more

8 mentions without citation

The Biological Synthesis and the Function of Mucin 2 in Pseudomyxoma Peritonei.
Lin et al. (2021)
7 more