› 6rqm

X-ray diffraction
3Å resolution

A blocking anti-CTLA-4 Nanobody (KN044) complexed with CTLA-4

Released:
DOI: 10.2210/pdb6rqm/pdb
PDB entry 6rqm coloured by chain, front view.
PDB entry 6rqm coloured by chain, side view.
PDB entry 6rqm coloured by chain, top view.
Source organisms:
Entry authors: Zhang F, Zhou A, Gao H

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-210686 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
A blocking anti-CTLA-4 nanobody (KN044) Chain: B
Molecule details ›
Chain: B
Length: 144 amino acids
Theoretical weight: 15.31 KDa
Source organism: Camelus bactrianus
Expression system: Homo sapiens
Cytotoxic T-lymphocyte protein 4 Chain: A
Molecule details ›
Chain: A
Length: 125 amino acids
Theoretical weight: 13.38 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P16410 (Residues: 37-161; Coverage: 67%)
Gene names: CD152, CTLA4
Sequence domains: Immunoglobulin V-set domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U1
Spacegroup: P6522
Unit cell:
a: 98.77Å b: 98.77Å c: 110.5Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.253 0.25 0.313
Expression system: Homo sapiens

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