› 6rr9

X-ray diffraction
3.43Å resolution

DNA/RNA binding protein

Released:
DOI: 10.2210/pdb6rr9/pdb
PDB entry 6rr9 coloured by chain, front view.
PDB entry 6rr9 coloured by chain, side view.
PDB entry 6rr9 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural and biochemical characterization of human Schlafen 5.
Metzner FJ, Huber E, Hopfner KP, Lammens K
Nucleic Acids Res 50 1147-1161 (2022)
PMID: 35037067

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-170715 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Schlafen family member 5 Chain: A
Molecule details ›
Chain: A
Length: 344 amino acids
Theoretical weight: 39.07 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q08AF3 (Residues: 1-336; Coverage: 38%)
Gene name: SLFN5
Sequence domains:

Ligands and Environments

3 bound ligands:
Ligand ZN 1 x ZN
Ligand SO4 5 x SO4
Ligand GOL 1 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06DA
Spacegroup: P3221
Unit cell:
a: 101.06Å b: 101.06Å c: 114.46Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.21 0.205 0.259
Expression system: Escherichia coli

Quick links

Citations

3 review citations

Progress in investigating the relationship between Schlafen5 genes and malignant tumors.
Tu et al. (2023)
2 more

3 mentions without citation

Structural, molecular, and functional insights into Schlafen proteins.
Jo et al. (2022)
2 more