Function and Biology Details
Reaction catalysed:
(1a) S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [HECT-type E3 ubiquitin transferase]-L-cysteine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + S-ubiquitinyl-[HECT-type E3 ubiquitin transferase]-L-cysteine
Sequence domains:
Structure analysis Details
Assembly composition:
monomeric (preferred)
Assembly name:
NEDD4-like E3 ubiquitin-protein ligase WWP2 (preferred)
PDBe Complex ID:
PDB-CPX-126241 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
NEDD4-like E3 ubiquitin-protein ligase WWP2
Molecule details ›
Chain: A
Length: 109 amino acids
Theoretical weight: 11.97 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
Sequence domains: WW domain
Length: 109 amino acids
Theoretical weight: 11.97 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
- Canonical:
O00308 (Residues: 438-480; Coverage: 5%)
Sequence domains: WW domain
Ligands and Environments
No bound ligands
No modified residues
Experiments and Validation Details
Chemical shift assignment:
92%
Refinement method:
molecular dynamics
Expression system: Escherichia coli BL21(DE3)
