› 6ruu

X-ray diffraction
2.95Å resolution

Pseudokinase domain of human IRAK3

Released:
DOI: 10.2210/pdb6ruu/pdb
PDB entry 6ruu coloured by chain, front view.
PDB entry 6ruu coloured by chain, side view.
PDB entry 6ruu coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Dimeric Structure of the Pseudokinase IRAK3 Suggests an Allosteric Mechanism for Negative Regulation.
Lange SM, Nelen MI, Cohen P, Kulathu Y
Structure 29 238-251.e4 (2021)
PMID: 33238146

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-195327 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Interleukin-1 receptor-associated kinase 3 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 315 amino acids
Theoretical weight: 36.18 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q9Y616 (Residues: 145-454; Coverage: 52%)
Gene name: IRAK3
Sequence domains: Protein kinase domain

Ligands and Environments

3 bound ligands:
Ligand HG 8 x HG
Ligand GOL 3 x GOL
Ligand SO4 8 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I24
Spacegroup: P21212
Unit cell:
a: 53.55Å b: 167.16Å c: 179.51Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.23 0.228 0.26
Expression system: Spodoptera frugiperda

Quick links

Citations

5 review citations

IRAK1 and IRAK4 as emerging therapeutic targets in hematologic malignancies.
Bennett et al. (2022)
4 more

6 mentions without citation

There's more to death than life: Noncatalytic functions in kinase and pseudokinase signaling.
Mace et al. (2021)
5 more