› 6rvh

X-ray diffraction
3Å resolution

NADH-dependent Coenzyme A Disulfide Reductase soaked with Menadione

Released:
DOI: 10.2210/pdb6rvh/pdb
PDB entry 6rvh coloured by chain, front view.
PDB entry 6rvh coloured by chain, side view.
PDB entry 6rvh coloured by chain, top view.
Source organism: Thermus thermophilus
Primary publication:
Characterization and X-ray structure of the NADH-dependent coenzyme A disulfide reductase from Thermus thermophilus.
Lencina AM, Koepke J, Preu J, Muenke C, Gennis RB, Michel H, Schurig-Briccio LA
Biochim Biophys Acta Bioenerg 1860 148080 (2019)
PMID: 31520616

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-180822 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
NADH oxidase Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 443 amino acids
Theoretical weight: 47.92 KDa
Source organism: Thermus thermophilus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q72HK3 (Residues: 1-443; Coverage: 100%)
Gene name: TT_C1484
Sequence domains:

Ligands and Environments

3 bound ligands:
Ligand FAD 4 x FAD
Ligand COA 4 x COA
Ligand VK3 4 x VK3
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I03
Spacegroup: P42212
Unit cell:
a: 159.95Å b: 159.95Å c: 255.93Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.216 0.215 0.259
Expression system: Escherichia coli

Quick links

Citations

1 citations in other articles

Analysis of disulphide bond linkage between CoA and protein cysteine thiols during sporulation and in spores of Bacillus species.
Zhyvoloup et al. (2020)

1 mention without citation

Pharmacological Characterization of 4-Methylthioamphetamine Derivatives.
Guajardo et al. (2020)