Function and Biology Details
Reactions catalysed:
3'-end directed exonucleolytic cleavage of viral RNA-DNA hybrid
Endohydrolysis of RNA in RNA/DNA hybrids. Three different cleavage modes: 1. sequence-specific internal cleavage of RNA. Human immunodeficiency virus type 1 and Moloney murine leukemia virus enzymes prefer to cleave the RNA strand one nucleotide away from the RNA-DNA junction. 2. RNA 5'-end directed cleavage 13-19 nucleotides from the RNA end. 3. DNA 3'-end directed cleavage 15-20 nucleotides away from the primer terminus.
Biochemical function:
Biological process:
Cellular component:
- not assigned
Structure analysis Details
Assembly composition:
hetero hexadecamer (preferred)
Assembly name:
Pol protein and DNA (preferred)
PDBe Complex ID:
PDB-CPX-120581 (preferred)
Entry contents:
1 distinct polypeptide molecule
2 distinct DNA molecules
2 distinct DNA molecules
Macromolecules (3 distinct):
Pol protein
Molecule details ›
Chains: A, B, C, D, E, F, I, J, K, L, M, N
Length: 290 amino acids
Theoretical weight: 32.73 KDa
Source organism: Simian immunodeficiency virus
Expression system: Escherichia coli
UniProt:
Sequence domains:
Length: 290 amino acids
Theoretical weight: 32.73 KDa
Source organism: Simian immunodeficiency virus
Expression system: Escherichia coli
UniProt:
- Canonical:
E1ANT8 (Residues: 735-1023; Coverage: 28%)
Sequence domains:
