› 6rx3

X-ray diffraction
2.2Å resolution

Crystal structure of human syncytin 2 in post-fusion conformation

Released:
DOI: 10.2210/pdb6rx3/pdb
PDB entry 6rx3 coloured by chain, front view.
PDB entry 6rx3 coloured by chain, side view.
PDB entry 6rx3 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
X-ray Structures of the Post-fusion 6-Helix Bundle of the Human Syncytins and their Functional Implications.
Ruigrok K, Vaney MC, Buchrieser J, Baquero E, Hellert J, Baron B, England P, Schwartz O, Rey FA, Backovic M
J Mol Biol 431 4922-4940 (2019)
PMID: 31711961

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-158028 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transmembrane protein Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 108 amino acids
Theoretical weight: 12.2 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P60508 (Residues: 375-468; Coverage: 18%)
Gene names: ERVFRD-1, ERVFRDE1, UNQ6191/PRO20218
Sequence domains: ENV polyprotein (coat polyprotein)

Ligands and Environments

1 bound ligand:
Ligand CL 1 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SOLEIL BEAMLINE PROXIMA 2
Spacegroup: P3221
Unit cell:
a: 91.416Å b: 91.416Å c: 69.725Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.216 0.214 0.256
Expression system: Escherichia coli BL21(DE3)

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Citations

3 citation in other articles

Human Endogenous Retrovirus Type W Envelope from Multiple Sclerosis Demyelinating Lesions Shows Unique Solubility and Antigenic Characteristics.
Charvet et al. (2021)
2 more

4 mentions without citation

A Frame-by-Frame Glance at Membrane Fusion Mechanisms: From Viral Infections to Fertilization.
Azimi et al. (2023)
3 more