› 6s4m

X-ray diffraction
2.4Å resolution

Crystal structure of the human organic anion transporter MFSD10 (TETRAN)

Released:
DOI: 10.2210/pdb6s4m/pdb
PDB entry 6s4m coloured by chain, front view.
PDB entry 6s4m coloured by chain, side view.
PDB entry 6s4m coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Pascoa TC, Pike ACW, Bushell SR, Quigley A, Chu A, Mukhopadhyay SMM, Shrestha L, Venkaya S, Chalk R, Burgess-Brown NA, Edwards AM, Arrowsmith CH, Bountra C, Carpenter EP, Structural Genomics Consortium (SGC)

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-172091 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Major facilitator superfamily domain-containing protein 10 Chain: A
Molecule details ›
Chain: A
Length: 451 amino acids
Theoretical weight: 48.04 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q14728 (Residues: 1-444; Coverage: 98%)
Gene names: MFSD10, TETRAN
Sequence domains: Sugar (and other) transporter

Ligands and Environments

2 bound ligands:
Ligand OLC 2 x OLC
Ligand CIT 1 x CIT
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I24
Spacegroup: P21
Unit cell:
a: 55.994Å b: 70.375Å c: 63.44Å
α: 90° β: 115.45° γ: 90°
R-values:
R R work R free
0.211 0.209 0.258
Expression system: Spodoptera frugiperda

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