› 6s8f

Electron Microscopy
4Å resolution

Structure of nucleotide-bound Tel1/ATM

Released:
DOI: 10.2210/pdb6s8f/pdb
PDB entry 6s8f coloured by chain, front view.
PDB entry 6s8f coloured by chain, side view.
PDB entry 6s8f coloured by chain, top view.
Source organism: Saccharomyces cerevisiae
Primary publication:
Cryo-EM Structure of Nucleotide-Bound Tel1ATM Unravels the Molecular Basis of Inhibition and Structural Rationale for Disease-Associated Mutations.
Yates LA, Williams RM, Hailemariam S, Ayala R, Burgers P, Zhang X
OpenAccess logo Structure 28 96-104.e3 (2020)
PMID: 31740029
Related structures: EMD-10120

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-153546 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serine/threonine-protein kinase TEL1 Chains: F, H
Molecule details ›
Chains: F, H
Length: 2788 amino acids
Theoretical weight: 292.58 KDa
Source organism: Saccharomyces cerevisiae
Expression system: Saccharomyces cerevisiae
UniProt:
  • Canonical: P38110 (Residues: 968-2787; Coverage: 65%)
Gene names: TEL1, YBL0706, YBL088C
Sequence domains:

Ligands and Environments

2 bound ligands:
Ligand ANP 2 x ANP
Ligand MG 2 x MG
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this EM entry.
Resolution: 4Å
Relevant EMDB volumes: EMD-10120
Expression system: Saccharomyces cerevisiae

Quick links

Citations

6 review citations

Cellular functions of the protein kinase ATM and their relevance to human disease.
Lee et al. (2021)
5 more

3 mentions without citation

Cryo-EM Structure of Nucleotide-Bound Tel1ATM Unravels the Molecular Basis of Inhibition and Structural Rationale for Disease-Associated Mutations.
Yates et al. (2020)
2 more