6s8j

Electron Microscopy
2.91Å resolution

Structure of ZEBOV GP in complex with 5T0180 antibody

Released:
Source organisms:
Primary publication:
Structural Basis for a Convergent Immune Response against Ebola Virus.
Cell Host Microbe 27 418-427.e4 (2020)
PMID: 32059794
Related structures: EMD-10124

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dodecamer (preferred)
PDBe Complex ID:
PDB-CPX-238783 (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (5 distinct):
Light Chain Chains: L, O, U
Molecule details ›
Chains: L, O, U
Length: 218 amino acids
Theoretical weight: 23.13 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Heavy Chain Chains: H, P, Y
Molecule details ›
Chains: H, P, Y
Length: 231 amino acids
Theoretical weight: 24.64 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
GP1 Chains: A, C, E
Molecule details ›
Chains: A, C, E
Length: 323 amino acids
Theoretical weight: 35.71 KDa
Source organism: Ebola virus
Expression system: Homo sapiens
UniProt:
  • Canonical: Q05320 (Residues: 32-501; Coverage: 49%)
Gene name: GP
Sequence domains: Filovirus glycoprotein
GP2 Chains: B, D, F
Molecule details ›
Chains: B, D, F
Length: 168 amino acids
Theoretical weight: 18.99 KDa
Source organism: Ebola virus
Expression system: Homo sapiens
UniProt:
  • Canonical: Q05320 (Residues: 502-632; Coverage: 20%)
Gene name: GP

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.91Å
Relevant EMDB volumes: EMD-10124
Expression system: Homo sapiens