› 6san

X-ray diffraction
1.36Å resolution

SALSA / DMBT1 / GP340 SRCR domain 8 soaked in calcium and magnesium

Released:
DOI: 10.2210/pdb6san/pdb
PDB entry 6san coloured by chain, front view.
PDB entry 6san coloured by chain, side view.
PDB entry 6san coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structures of SALSA/DMBT1 SRCR domains reveal the conserved ligand-binding mechanism of the ancient SRCR fold.
Reichhardt MP, Loimaranta V, Lea SM, Johnson S
Life Sci Alliance 3 (2020)
PMID: 32098784

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-193718 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Deleted in malignant brain tumors 1 protein Chains: A, B
Molecule details ›
Chains: A, B
Length: 137 amino acids
Theoretical weight: 14.67 KDa
Source organism: Homo sapiens
Expression system: Drosophila melanogaster
UniProt:
  • Canonical: Q9UGM3 (Residues: 986-1094; Coverage: 5%)
Gene names: DMBT1, GP340
Sequence domains: Scavenger receptor cysteine-rich domain

Ligands and Environments

3 bound ligands:
Ligand MG 6 x MG
Ligand CL 2 x CL
Ligand GOL 2 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I03
Spacegroup: P21
Unit cell:
a: 27.235Å b: 46.643Å c: 93.628Å
α: 90° β: 97.366° γ: 90°
R-values:
R R work R free
0.191 0.189 0.226
Expression system: Drosophila melanogaster

Quick links

Citations

3 review citations

S Protein, ACE2 and Host Cell Proteases in SARS-CoV-2 Cell Entry and Infectivity; Is Soluble ACE2 a Two Blade Sword? A Narrative Review.
Nejat et al. (2023)
2 more

1 mention without citation

Structures of SALSA/DMBT1 SRCR domains reveal the conserved ligand-binding mechanism of the ancient SRCR fold.
Reichhardt et al. (2020)