› 6scj

Electron Microscopy
3.6Å resolution

The structure of human thyroglobulin

Released:
DOI: 10.2210/pdb6scj/pdb
PDB entry 6scj coloured by chain, front view.
PDB entry 6scj coloured by chain, side view.
PDB entry 6scj coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The structure of human thyroglobulin.
Coscia F, Taler-Verčič A, Chang VT, Sinn L, O'Reilly FJ, Izoré T, Renko M, Berger I, Rappsilber J, Turk D, Löwe J
Nature 578 627-630 (2020)
PMID: 32025030
Related structures: EMD-10141

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-134138 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Thyroglobulin Chains: A, B
Molecule details ›
Chains: A, B
Length: 2768 amino acids
Theoretical weight: 305.07 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P01266 (Residues: 1-2768; Coverage: 100%)
Gene name: TG
Sequence domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA
Carbohydrate polymer
1 bound ligand:
Ligand NAG 30 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.6Å
Relevant EMDB volumes: EMD-10141
Expression system: Homo sapiens

Quick links

Citations

12 review citations

Cellular and molecular basis of thyroid autoimmunity.
Bogusławska et al. (2022)
11 more

7 mentions without citation

Current View on EpCAM Structural Biology.
Gaber et al. (2020)
6 more