› 6sen

X-ray diffraction
1.65Å resolution

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-172327 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Transcriptional enhancer factor TEF-3 Chains: A, B
Molecule details ›
Chains: A, B
Length: 220 amino acids
Theoretical weight: 25.81 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q15561 (Residues: 217-434; Coverage: 50%)
Gene names: RTEF1, TCF13L1, TEAD4, TEF3
Sequence domains: YAP binding domain
Protein FAM181A Chains: L, M
Molecule details ›
Chains: L, M
Length: 18 amino acids
Theoretical weight: 2 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q8N9Y4 (Residues: 190-205; Coverage: 5%)
Gene names: C14orf152, FAM181A, HSD-31, HSD31

Ligands and Environments

1 bound ligand:
Ligand SO4 5 x SO4
1 modified residue:
Ligand MYK 2 x MYK

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: C2
Unit cell:
a: 66.49Å b: 132.07Å c: 62.02Å
α: 90° β: 115.87° γ: 90°
R-values:
R R work R free
0.191 0.19 0.219
Expression systems:
  • Escherichia coli
  • Not provided

Quick links

Citations

1 review citation

The Hippo signaling pathway in gastric cancer.
Cao et al. (2023)
8 other articles

3 mentions without citation

Leveraging Hot Spots of TEAD-Coregulator Interactions in the Design of Direct Small Molecule Protein-Protein Interaction Disruptors Targeting Hippo Pathway Signaling.
Zhao et al. (2023)
2 more