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› 6sfu

X-ray diffraction
1.04Å resolution

Human Carbonic Anhydrase II in complex with a furan-containing benzenesulfonamide

Released:
DOI: 10.2210/pdb6sfu/pdb
Model geometry
Fit model/data
PDB entry 6sfu coloured by chain, front view.
PDB entry 6sfu coloured by chain, side view.
PDB entry 6sfu coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Gloeckner S, Heine A, Klebe G

Function and Biology Details

Reactions catalysed: 
hydrogencarbonate + H(+) = CO2 + H2O.
urea = cyanamide + H2O.
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-133681 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Carbonic anhydrase 2 Chain: A
Molecule details ›
Chain: A
Length: 265 amino acids
Theoretical weight: 29.81 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P00918 (Residues: 1-260; Coverage: 100%)
Gene name: CA2
Sequence domains: Eukaryotic-type carbonic anhydrase

Ligands and Environments

6 bound ligands:
Ligand ZN 1 x ZN
Ligand HG 1 x HG
Ligand DMS 1 x DMS
Ligand NA 2 x NA
Ligand BE7 1 x BE7
Ligand LBQ 2 x LBQ
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: ELETTRA BEAMLINE 11.2C
Spacegroup: P21
Unit cell:
a: 42.447Å b: 41.62Å c: 72.401Å
α: 90° β: 104.564° γ: 90°
R-values:
R R work R free
0.126 0.126 0.138
Expression system: Escherichia coli BL21(DE3)

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