› 6shs

Electron Microscopy
4.4Å resolution

Abeta fibril (Morphology I)

Released:
DOI: 10.2210/pdb6shs/pdb
PDB entry 6shs coloured by chain, front view.
PDB entry 6shs coloured by chain, side view.
PDB entry 6shs coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Cryo-EM structure and polymorphism of Aβ amyloid fibrils purified from Alzheimer's brain tissue.
Kollmer M, Close W, Funk L, Rasmussen J, Bsoul A, Schierhorn A, Schmidt M, Sigurdson CJ, Jucker M, Fändrich M
Nat Commun 10 4760 (2019)
PMID: 31664019
Related structures: EMD-10204

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dodecamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-138392 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Amyloid-beta protein 40 Chains: A, B, C, D, E, F, G, H, I, J, K, L
Molecule details ›
Chains: A, B, C, D, E, F, G, H, I, J, K, L
Length: 40 amino acids
Theoretical weight: 4.34 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P05067 (Residues: 672-711; Coverage: 5%)
Gene names: A4, AD1, APP
Sequence domains: Beta-amyloid peptide (beta-APP)

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 4.4Å
Relevant EMDB volumes: EMD-10204

Quick links

Citations

56 review citations

Proteostasis of Islet Amyloid Polypeptide: A Molecular Perspective of Risk Factors and Protective Strategies for Type II Diabetes.
Milardi et al. (2021)
55 more

29 mentions without citation

The Cryo-EM Effect: Structural Biology of Neurodegenerative Disease Aggregates.
Creekmore et al. (2021)
28 more